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  • 1
    Electronic Resource
    Electronic Resource
    Sorbinil does not prevent galactose-induced glomerular capillary basement membrane thickening in the rat (1990)
    Springer
    Diabetologia 33 (1990), S. 515-521 
    Details
    ISSN: 1432-0428
    Keywords: Basement membrane ; galactosaemia ; aldose reductase inhibitors ; glomerulus ; microvessels
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We investigated the role of the polyol pathway in the pathogenesis of glomerular basement membrane thickening in galactosaemic rats, an animal model that develops basement membrane lesions comparable to those of human diabetic subjects. Normotensive Wistar-Kyoto rats fed a 30% galactose diet for nine months developed significant glomerular basement membrane thickening by comparison with rats on a control test diet (p=0.008). However, addition of an aldose reductase inhibitor, sorbinil (250 mg/kg diet), to the galactose diet did not prevent the increase in glomerular basement membrane thickness. Furthermore, by using a quantitative electron microscopic immunogold technique, we examined biochemical alterations in the composition of glomerular basement membranes in this animal model. The labelling density (comparable to relative concentration) of collagen type IV in thickened glomerular basement membranes of galactosaemic animals was significantly increased by comparison to those of control rats (p=0.015). However, there was no significant difference in labelling densities of laminin and heparan sulfate proteoglycan core protein of these animals. Thus, our results indicate that an increase in glomerular basement membrane thickness accompanied by an increase in the labelling density of collagen type IV occurs in the galactosaemic rats, but this thickening is not prevented by sorbinil at the dose used in this experiment. Our study raises the strong possibility that glomerular basement membrane thickening in galactosaemic rats may not be due to excessive polyol pathway activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00404137
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  • 2
    Electronic Resource
    Electronic Resource
    Doubly excited3Se,3De and3Ge states of two-electron atomic systems (1994)
    Springer
    Theoretical chemistry accounts 89 (1994), S. 147-155 
    Details
    ISSN: 1432-2234
    Keywords: Doubly excited states ; Excitation energies ; Effective quantum numbers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary Time-dependent perturbation theory has been applied to calculate the doubly excited triplet statesNsns:3Se,Npnp:3De andNdnd:3Ge (N=2, 3, 4,n=N+1, ... ,5) for He, Li+, Be2+ and B3+. A time-dependent harmonic perturbation causes simulataneous excitation of both the electrons with a change of spin state. The doubly excited energy levels have been identified as the poles of an appropriately constructed linearized variational functional with respect to the driving frequency. In addition to the transition energies, effective quantum numbers of these doubly excited states have been calculated and analytic representations of their wave functions are obtained. These are utilized to estimate the Coulomb repulsion term for these states which checks the consistency of the wave functions. These wave functions may also be used for calculating other physical properties of the systems.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01132798
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    Paper (German National Licenses)
    Fulltext
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