Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • 1990-1994  (24)
  • 1980-1984  (14)
  • Chemistry  (36)
  • Brain self-stimulation  (2)
  • Granulosa lutein cells
  • 1
    Electronic Resource
    Electronic Resource
    Threshold differences for naloxone and naltrexone in the hypothalamus and midbrain using fixed ratio brain self-stimulation in rats (1981)
    Springer
    Psychopharmacology 74 (1981), S. 17-22 
    Details
    ISSN: 1432-2072
    Keywords: Brain self-stimulation ; Fixed ratio reinforcement ; Morphine ; Naloxone ; Naltrexone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Rats were implanted with stimulating electrodes aimed either at the medial forebrain bundle-lateral hypothalamus (MFB-LH) or the midbrain-central gray (MID-GG), and were trained to lever-press for brain self-stimulation on a fixed ratio: 15 schedule of reinforcement. The dose-dependent effects of morphine (0.1–3.0 mg/kg), naloxone (0.1–30 mg/kg), and naltrexone (0.1–30 mg/kg) were then determined during 1 h test sessions. Both naloxone and naltrexone decreased the rate of responding in the MFB-LH as well as in the MID-CG. However, decrements in response rates were produced in the MID-CG by both naloxone and naltrexone at one tenth the doses required to produce similar decrements with electrodes in the MFB-LH. Dose-dependent decreases in response rates produced by morphine occurred at the same doses in the two electrode sites. At both sites, the decreases in response rates produced by the highest dose of morphine were antagonized completely by a low dose of naloxone (0.1 mg/kg). At an intermediate dose of naloxone (1.0 mg/kg), antagonism occurred in the MFB-LH but not in the MID-CG. At a high dose of naloxone (10 mg/kg), a depression in lever-pressing occurred at both sites in the morphine-treated animal indicating that the depressive action predominated over antagonism. These data explain the lack of consistency of the effects of naloxone on brain self-stimulation previously reported by different laboratories, and demonstrate that the use of partial reinforcement schedules in a rational approach to the evaluation of opioid effects on brain self-stimulation behavior.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00431750
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Acute effects of neuroleptics on brain self-stimulation thresholds in rats (1980)
    Springer
    Psychopharmacology 67 (1980), S. 9-15 
    Details
    ISSN: 1432-2072
    Keywords: Brain self-stimulation ; Thresholds ; Neuroleptics ; Haloperidol ; Loxapine ; Chlorpromazine ; Pimozide ; Clozapine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The acute effects of 5 neuroleptic drugs were tested in rats implanted with stimulating electrodes in the medial forebrain bundle and trained in a brain selfstimulation threshold procedure. Haloperidol (0.01–0.10 mg/kg) and loxapine (0.03–0.56 mg/kg) produced increases in reinforcement thresholds accompanied by reductions in response rates. Chlorpromazine (0.10–3.0 mg/kg) did not significantly alter reinforcement thresholds, but did produce dose-dependent reductions in response rates. Pimozide (0.1–1.75 mg/kg) was similar to chlorpromazine and significantly increased the reinforcement threshold only at the highest dose, although a graded decrease in response rates occurred over a wide dose-range. Clozapine (0.1–1.75 mg/kg) increased reinforcement thresholds without producing any significant changes in response rates, but when 3.0 mg/kg was administered, a marked disruption of behavior occurred. The results suggested that a distinction can be made between the effects of neuroleptics on motor behavior and on central reinforcement thresholds, and this may help in the interpretation of the relation between the chemical and clinical potency of antipsychotic drugs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00427589
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    π-Orbital Interactions in Möbius-Type Molecules as Studied by Photoelectron Spectroscopy (1982)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 65 (1982), S. 1743-1751 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Some benzobarrelenes were studied by photoelectron (PE.) spectroscopy. The results can be interpreted by considering dominant through-space interaction of the π-molecular fragments in a Möbius-fashion, Some chemical features of the substrates are rationalized on the basis of these findings.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19820650609
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Heterocyclen mit einem Azaallyl-System, 4. 5H-Dibenz[c,e]azepine mit Donor-Gruppen in 7-Stellung (1991)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 124 (1991), S. 2085-2090 
    Details
    ISSN: 0009-2940
    Keywords: 5H-Dibenz[c,e]azepines ; Imidates ; alkyl ; heterocyclic ; Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Heterocycles with an Azaallyl System, 4.  -  5H-Dibenz[c,e]azepines with Donor Groups at the 7-Position5H-Dibenz[c,e]azepines substituted with a methoxy (1) or methylthio group (10) at the 7-position have been synthesized from 6,7-dihydro-5H-dibenz[c,e]azepin-5-one (5) by regioselective O- or S-alkylation with methyl trifluoromethansulfonate and subsequent NH-deprotonation. According to the spectroscopic properties the semicyclic 7-membered alkyl imidates exist exclusively in the benzenoid 5H structure.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19911240934
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Mechanisms of Diazo Coupling Reactions. Part XXXII. The Diazoamino Rearrangement in 20% Acetonitrile/Aqueous BuffersPart XXXI: [1]. (1982)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 65 (1982), S. 122-132 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The rearrangements of 4′-methoxy-N-methyl- and N-methyl-4′-nitro-diatzoaminobenzene have been studied in 20% acetonitrile/aqueous buffers. The reactions are specifically acid catalyzed and involve pre-equilibrium formation of amine and diazonium salt followed by rate-limiting attack of the diazonium ion at a C-atom (C-coupling) to give the corresponding aminoazo compounds. There is no evidence to suggest that, under the present conditions, mechanisms other than the established Friswell-Green mechanism occur. The traditional two-stage synthesis of aminoazo compounds via isolated diazoamino compounds can therefore be replaced by a one stage process for amines which undergo initial attack at a N-atom by diazonium ion (N-coupling).
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19820650112
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Transport Properties of H+-Selective Membranes Containing Amine-Derivative Ionophores and Mobile Sites (1993)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 76 (1993), S. 407-415 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Transport processes in plasticized PVC membranes containing the H+ chromoionophore ETH 5294 and additional tetraphenylborate-type mobile sites were analyzed by employing the potential-step method. Using chronoamperometry, impedance spectroscopy, and UV/VIS absorbance measurements, it is shown that the ionophore behaves as a carrier for protons, when the membranes are immersed between two aqueous solutions. It was possible to document the changes in the concentration profiles of both free ionophores and ionic species in some of the membranes. There is no evidence of proton hopping between the ionophores.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19930760124
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Untersuchungen zur Chemie von Isoindolen und Isoindoleninen, XXXVII. Symmetrisch substituierte 2-Alkyl-2H-isoindole (1990)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 123 (1990), S. 1719-1727 
    Details
    ISSN: 0009-2940
    Keywords: Isoindoles, symmetrically substituted ; Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Studies on the Chemistry of Isoindoles and Isoindolenines, XXXVII1) - Symmetrically Substituted 2-Alkyl-2H-isoindoles2-Alkyl-Rn-2H-isoindoles (1; Rn=4,5,6,7-tetramethyl, 4,5,6,7-tetrachloro) have been prepared efficiently by the N-oxide route and characterized by spectroscopic means.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19901230823
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Struktur und Reaktivität von isoanellierten heterocyclischen Systemen mit 4n;-π- und (4n + 2)-π-Elektronen, XVIII. Benzo[c]thiophene mit symmetrischer Struktur: Modifizierte und optimierte Herstellung nach der S-Oxid-Route (1991)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 124 (1991), S. 645-654 
    Details
    ISSN: 0009-2940
    Keywords: Benzo[c]thiophenes ; preparation by the S-oxide route ; Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Structure and Reactivity of Isoannullated Heterocyclic Systems with 4n;-π and (4n + 2)-π Electrons, XVIII. - Benzo[c]thiophenes with Symmetric Structure: Modified and Optimized Preparation by the S-Oxide RouteBenzo[c]thiophenes (15) with symmetric structure have been prepared efficiently from 1,3-dihydrobenzo[c]thiophene 2-oxides (9) by reaction with aluminium oxide, by O-acylation with trifluoroacetic anhydride, or O-alkylation with methyl trifluoromethanesulfonate. The aromatization of the S-oxides 9 is achieved by O-functionalization, subsequent elimination, and consecutive deprotonation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19911240332
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Untersuchungen zur Chemie von Isoindolen und Isoindoleninen, XXXIX. Reaktionen von 2-Alkyl-4,5,6,7-Rn-2H-isoindolen (Rn=tetramethyl, tetrachlor) mit aktivierten C=C-Dienophilen (1992)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 125 (1992), S. 183-189 
    Details
    ISSN: 0009-2940
    Keywords: 2H-Isoindoles, 2-alkyl-, reactions with C=C dienophiles ; Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Studies on the Chemistry of Isoindoles and Isoindolenines, XXXIX.  -  Reactions of 2-Alkyl-4,5,6,7-Rn-2H-isoindoles (Rn=tetramethyl, tetrachloro) with Activated C=C DienophilesSubstituted 2H-Isoindoles 2 react with maleic imides in absolute ether. Cycloaddition in 1,3-position leads to the formation of 1:1 adducts. The ratio between endo isomers 4 and exo isomers 5 depends on the substituents and the solvents. In the case of steric hindrance the Diels-Alder addition can be induced by Lewis acids. In the presence of oxygen-substituted 4,5,6,7-tetrachloro-2-methylisoindolin-1-ones 7 are formed as minor products.
    Additional Material: 6 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19921250130
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    Untersuchungen zur Chemie von Isoindolen und Isoindoleninen, XXXVI1. Reaktionen von 2-Alkyl-2H-isoindolen mit Maleinimiden (1990)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 123 (1990), S. 381-390 
    Details
    ISSN: 0009-2940
    Keywords: o-Quinoid hetarenes / Isoindoles, cycloaddition reactions with / Dienophiles, CC ; Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Studies on the Chemistry of Isoindoles and Isoindolenines, XXXVI - Reactions of 2-Alkyl-2H-isoindoles with Maleic Imides2-Alkyl-2H-isoindoles 2 react with maleic imides 4 exclusively in position 1 and 3 by cycloaddition to form Diels-Alder adducts. The transformation of the endo isomers 6 into the thermodynamically more stable exo isomers 7 depends on the dienophile. The cycloaddition is useful for analytical detection of o-quinoid hetarenes 2 and for the synthesis of 7-azabicyclo[2.2.1]heptenes.
    Additional Material: 3 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19901230225
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...