ISSN:
1432-069X
Keywords:
Scleroderma fibroblast
;
Growth
;
Lymphoid cell-derived fibroblast growth factor
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Reactivity of scleroderma fibroblasts to lymphoid cell-derived fibroblast growth factor (FGF) was assessed in this study. The fibroblasts from the sclerotic lesion failed to respond to FGF, whereas those from scleroedematous lesions responded equally to normal fibroblast. Response of the fibroblast from sclerotic lesion was also lower than that of the fibroblast from mature scar. Fibroblasts obtained from three different layers of healthy skin, papillary dermis, reticular dermis, and reticular-subcutaneous layer, responded equally to FGF, whereas the fibroblast of reticular dermis from sclerotic lesion failed to respond to FGF. It is suggested that the fibroblast of reticuar dermis in scleroderma is variously activated by some unknown factors, so that they do not have enough reserve to respond to further stimuli.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00414232
Permalink
