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  • 1990-1994  (2)
  • 1980-1984  (1)
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  • 1
    Electronic Resource
    Electronic Resource
    Effect of levamisole on cytotoxic T-cell-mediated immune resistance to L1210 murine leukemia in hyperimmune mice (1984)
    Springer
    Cancer immunology immunotherapy 17 (1984), S. 195-199 
    Details
    ISSN: 1432-0851
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of levamisole (LMS) on T-cell-mediated antitumor immunity was examined in adult and aged mice hyperimmune to L1210 leukemia. The immune resistance of aged mice was depressed compared with that of adult mice, which almost completely rejected 5×107 L1210 cells inoculated IP. A significant level of tumor-specific cytotoxicity was detected in the spleen cells of adult hyperimmune mice by the 51Cr-release assay after in vitro sensitization with mitomycin C-treated L1210 cells. This was mediated by cytotoxic T cells, since in vivo administration of antithymocyte serum or in vitro treatment of the spleen cells with anti-Thy 1.2 antibody and complement abrogated the cytotoxicity completely. In aged mice, however, cytotoxic T-cell activity was lower although the animals were immune to L1210. Administration of LMS (0.38 mg/kg) restored the depressed cytotoxicity of aged mice to the level seen in adult mice. Furthermore, in adult hyperimmune mice LMS augmented T-cell-mediated cytotoxic activity and restored the reduced cytotoxicity caused by in vivo administration of antithymocyte serum. These results indicate that LMS was effective in augmenting T-cell-mediated tumor immunity in immunologically competent or deficient hosts.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00205485
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Disposition and metabolism of KW-2149, a novel anticancer agent (1993)
    Springer
    Cancer chemotherapy and pharmacology 32 (1993), S. 143-150 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract KW-2149 is a new derivative of mitomycin C (MMC). The plasma concentrations, distribution, metabolism, and excretion of [3H]-KW-2149 in normal and tumor-bearing mice after i. v. administration of 16.6 mg/kg were investigated. The plasma radioactivity decreased biexponentially after i. v. administration in normal mice. However, the unchanged drug disappeared rapidly, showing a half-life (t 1/2) of 9.7 min, which was shorter than MMC's (18 min). The radioactivity was excreted in mouse urine (33%) and feces (58%) within 144 h. High radioactivity was distributed in the gallbladder, liver, kidney, pancreas, and lung at 1 h after i. v. administration to normal mice. The tumor concentration was lower than the plasma or blood concentration. The lowest radioactivity was observed in the brain. The metabolic rate of KW-2149 was very rapid. The methyl sulfide form (M-16), the symmetrical disulfide dimer (M-18), and the albumin conjugate were detected in plasma, which possessed anticellular activity. The specific anticellular activity of these compounds against uterine carcinoma (HeLa S3) was 1/100, 1, and 1/20 respectively, as compared with that of KW-2149.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00685618
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Guided bone tissue elaboration by osteogenic cells in vitro (1993)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 27 (1993), S. 429-431 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Primary rat bone marrow cells were cultured for 2 weeks in polystyrene dishes whose surfaces had been roughened using 600- or 320-grit silicon carbide paper. Eight samples were prepared of each of the three groups of dishes, to include a nontreated control suface. Following the culture period, the dishes were stained by von Kossa's method. The distribution of bone formed during the culture period was examined by light microscopy and the area of bone formed quantified. Results demonstrated that both the amount and spatial distribution of bone were influenced by the roughness of the underlying substratum. Differences between the smooth and roughened surfaces were statistically different at P 〈 .05. © 1993 John Wiley & Sons, Inc.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820270403
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    Paper (German National Licenses)
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