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  • 1
    Electronic Resource
    Electronic Resource
    CYCLIC 3′5′-ADENOSINE MONOPHOSPHATE AND CENTRAL CIRCULATORY CONTROL IN CATS AND DOGS (1977)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 4 (1977), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. Dibutyryl cyclic AMP (Db CAMP, 75–500 μg/kg), injected into the lateral ventricle of the brain of the cat increased blood pressure, heart rate and splanchnic discharge rate.2. ATP, but not AMP, induced similar changes; GMP in small doses increased blood pressure.3. A number of drugs are known to activate adenylate cyclase-induced hypertension, tachycardia and increase splanchnic discharge rate. This was shown for TRH, tetracosactide and a new β2-adrenoceptor stimulant, NAB 365.4. Injection into the lateral ventricle of theophylline or Ro 7/ 2956, both inhibitors of phosphodiesterase, similarly increased blood pressure.5. Histamine administered by the same route induced similar reactions; it is not known if this action was exerted by activation of H1- or H2-receptors.6. Somatostatin, known to reduce cAMP levels, induced a small but significant decrease in blood pressure. Melanocyte stimulating hormone release inhibiting factor (MIF) and TSH were ineffective.7. These results provide evidence for the possibility of a role for cAMP in the central regulation of blood pressure at suprabulbar levels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1977.tb02671.x
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  • 2
    Electronic Resource
    Electronic Resource
    Measurements of the total cross section differenceΔσ Т innp transmission between 0.86 and 0.94 GeV (1994)
    Springer
    The European physical journal 61 (1994), S. 53-57 
    Details
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract We present results of the total cross section differenceΔσ Т obtained in transmission measurements at the energies 0.86, 0.88, 0.91 and 0.94 GeV. The SATURNE II polarized beam of free neutrons obtained from the break-up of polarized deuterons was transmitted through the polarized Saclay frozen-spin proton target. The beam and target polarizations were oriented in the vertical direction. The present results agree with previous SATURNE measurements and improve the amplitude analysis in the forward direction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01641886
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  • 3
    Electronic Resource
    Electronic Resource
    An experimental study of the antineutron-light nucleus annihilation at 1.4 GeV/c (1979)
    Springer
    The European physical journal 292 (1979), S. 197-203 
    Details
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The heavy liquid bubble chamber, Gargamelle, has been used to investigate the gross features of the annihilation of antineutrons in light nuclei (mainly Carbon). Results are presented on the distributions of multiplicity, momentum and emission angle for charged pions and protons together with a simple model to describe them.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01441626
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  • 4
    Electronic Resource
    Electronic Resource
    The optical gap of NiO (1992)
    Springer
    The European physical journal 86 (1992), S. 207-215 
    Details
    ISSN: 1434-6036
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The nature of the optical absorption gap in NiO at 4.0 eV is investigated. It is found that this gap is due to a band to band transition, where an electron is taken out of the valence band and placed into the conduction band. The optical gap of 6.0 eV found in Ni∶MgO is of a nature, where an electron is taken out of the oxygen 2p band and placed into the first affinity level of the Ni2+ ion (3d 8L»3d 9L−1). The impurity band created in Ni1−x Li x O by the Li ions is found 2.3 eV below the bottom of the conduction band in agreement with model predictions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01313827
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  • 5
    Electronic Resource
    Electronic Resource
    Calcium carbonate as a phosphate binder in dialysis patients: Evaluation of an enteric-coated preparation and effect of additional aluminium hydroxide on hyperaluminaemia (1991)
    Springer
    Journal of molecular medicine 69 (1991), S. 59-67 
    Details
    ISSN: 1432-1440
    Keywords: Calcium carbonate ; Phosphate ; Chronic renal failure ; Aluminium ; Hyperparathyroidism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Calcium carbonate has been successfully used as a phosphate binder in patients with chronic renal failure; however, a high frequency of hypercalcaemia has been reported. To study the effects of calcium carbonate preparations with different dissolution characteristics on the incidence of this side effect, we conducted a double-blind, crossover trial in 21 patients undergoing chronic haemodialysis. Aluminium hydroxide therapy was replaced with calcium carbonate. The subjects then randomly received either an enteric-coated or a gastric-coated preparation. Calcium carbonate (3.1–3.6 g/d) controlled serum phosphate concentrations as effectively as aluminium hydroxide (2.9 g/d). Concurrently, there was a significant rise in mean serum calcium and a fall in serum concentrations of both parathyroid hormone and osteocalcin, the latter suggesting a decrease in bone turnover. Overall, hypercalcaemic episodes developed in 9 patients (43%) and occurred at a considerable frequency (33 episodes per 100 patient-months) during treatment with the gastric-coated formulation. Following conversion to enteric-coated calcium carbonate (3.6 g/d) patients had fewer occurrences of hypercalcaemia (12 episodes per 100 patient-months,P〈0.05) and, as compared to the gastric-coated preparation, increases in serum calcium 〉3.00 mmol/l were not observed at all. Hyperaluminaemia was regressive during therapy with calcium carbonate, but addition of small doses of aluminium hydroxide caused a large rise in serum aluminium concentrations after infusion of desferrioxamine, indicating an enhanced rate of absorption or aberrant compartmentalization of aluminium. We conclude that calcium carbonate can control hyperphosphataemia in dialysis patients. However, undesirable hypercalcaemic episodes may occur, the frequency and severity of which can be lowered by the use of an enteric-coated preparation. Concomitant use of aluminium hydroxide and calcium carbonate should be restricted to patients in whom the degree of aluminium accumulation is monitored by serial desferrioxamine tests.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01666818
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  • 6
    Electronic Resource
    Electronic Resource
    Central sites and mechanisms of the hypotensive and bradycardic effects of the narcotic analgesic agent fentanyl (1977)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 296 (1977), S. 255-261 
    Details
    ISSN: 1432-1912
    Keywords: Baroreceptor reflex arc ; Carotid sinus nerve ; Centrally mediated vagal bradycardia ; Fentanyl ; Nucleus of the solitary tract
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In dogs, anaesthetized with chloralose, fentanyl (5 μg/kg i.v.) augmented the bradycardia produced by electrical stimulation of the carotid sinus nerves. In contrast, the same dose of the drug did not change the bradycardic response to stimulation of the nucleus of the solitary tract (NTS) indicating that a central facilitation of baroreceptor impulses occurs within the NTS, probably at the first synapse of baroreceptor reflex fibres. Bilateral destruction of the NTS caused a ful-minating hypertension and tachycardia similar to that after cutting the baroreceptor afferent fibres. After both procedures, fentanyl (20 μg/kg i.v.) produced marked hypotension and bradycardia. The bradycardic effect was abolished by cutting both vagal nerves when the dogs were pretreated with a β-adrenoceptor blocking agent (S 2395, 50 μg/kg i.v.). The results provide evidence that the NTS is not the main site of action either for the hypotensive effect or for the vagally mediated bradycardia of fentanyl. Since the dorsal nucleus of the vagal nerve was destroyed together with the NTS, this nucleus does also not appear to be a major site of the action of fentanyl. Blockade of dopamine receptors by haloperidol or pimozide or of serotonin receptors by methysergide did not change the hypotensive, bradycardic and sympathoinhibitory effects of fentanyl.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00498691
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  • 7
    Electronic Resource
    Electronic Resource
    Mikroskopische und elektronenmikroskopische Untersuchungen am Gitterfasersystem der Corpusmucosa während des Cyclus und der Gestation (1958)
    Springer
    Archives of gynecology and obstetrics 191 (1958), S. 212-223 
    Details
    ISSN: 1432-0711
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Es wurden licht- und elektronenmikroskopische Untersuchungen am Gitterfasersystem des Corpusendometriums vorgenommen. Dabei konnte festgestellt werden, daß das endometrane Fasergerüst, welches wahrscheinlich extracellulärer Herkunft ist, während des Cyclus und in der Gravidität charakteristischen Veränderungen unterworfen ist. Mehrere Tatsachen sprechen dafür, daß das Gitterfasersystem mit den zelligen Bestandteilen der Corpusmucosa eine anatomische und funktionelle Einheit bildet. Bei den Forschungen über das Corpusendometrium müssen daher beide Systeme gleichzeitig berücksichtigt werden.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00678863
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  • 8
    Electronic Resource
    Electronic Resource
    Typische Veränderungen Des Atp + Adp-Gehaltes Menschlichen Blutes Nach Kongorotinjektionen Bei Gesunden Und Leberkranken (1957)
    Springer
    Journal of molecular medicine 35 (1957), S. 1027-1029 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung 1. Nach intravenöser Injektion von kolloidalen Substanzen oder Kongorot steigen die Werte von ATP + ADP im Blut von Kaninchen und Menschen an. 2. Der zeitliche Ablauf dieses Anstiegs wird am besten durch Bestimmungen unmittelbar vor und 2, 4, 7 und 24 Std nach der Injektion erfaßt. Kurvenmäßig dargestellt ergeben die gewonnenen Werte relativ gleichförmige ansteigende und nach 4–7 Std wieder abfallende Kurven. 3. Derartige Kurven wurden an 40 Gesunden, 40 Leberkranken und der gleichen Zahl Patienten mit den verschiedensten anderen Krankheitengewonnen. 4. Mit hoher Regelmäßigkeit traten bei Leberkranken abfallende Werte auf, die bei andern Krankheiten nicht beobachtet werden. 5. Es wirken sich offenbar schon recht kleine Störungen der Leberfunktion in dem geschilderten Sinne aus, so daß durch Äthernarkose entstandene interkurrente Leberschäden noch 12–14 Tage lang nachgewiesen werden können.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01488729
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  • 9
    Electronic Resource
    Electronic Resource
    Die Aktivität Atp-dephosphorylierender Fermente im menschlichen Blut (1957)
    Springer
    Journal of molecular medicine 35 (1957), S. 661-663 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Bei den Erythrocyten finden sich 5–30% der ATP-spaltenden Fermentaktivität an der Oberfläche der unzerstörten Zelle. Nach Hämolyse werden in den bei 20 000 g abzentrifugierten und gewaschenen korpuskulären Bestandteilen 10 bis 30% gefunden. Unter den gegebenen Bedingungen nicht sedimentierbar sind 70–90%. Die Existenz eines Fermentes an den Erythrocytenoberflächen, das energiereiches Phosphat abbaut, läßt den Schluß zu, daß an den Erythrocytenoberflächen energieverbrauchende Prozesse stattfinden, die wohl zum Teil zum aktiven Stoffaustausch an den Membranen verwandt werden, gleichzeitig aber auch den Durchtritt dephosphorylierter Adeninderivate ermöglichen. Im Plasma findet sich eine ATP-Dephosphorylierung, die bei Hepatitiskranken verstärkt ist und nicht gleichsinnig mit der nachRaabe bestimmten alkalischen Phosphatase verläuft.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01481264
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  • 10
    Electronic Resource
    Electronic Resource
    Quantitative analysis of the size distribution of target-and targetoid fibres employing the method of daeves and beckel for mixed distributions (1979)
    Springer
    Acta neuropathologica 45 (1979), S. 215-220 
    Details
    ISSN: 1432-0533
    Keywords: Skeletal muscle ; Denervation atrophy ; Target fibres ; Analysis of size distribution
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An analysis of frequency distribution is performed in 250 target and targetoid fibres each from the anterior tibial muscle of a case with rapidly proceeding denervation atrophy. Following plane measurements on cross sections the size data were analysed according to the method of Daeves and Beckel [1] for mixed distributions. Three homogeneous normally distributed populations could thus be extracted from the mixed distributed sample. The largest population represents target fibres with a normal size range, while the second one encloses hypertrophic fibres, and the third and smallest one consists of fibres ranging within atrophic size limits. These findings support the previous presumption that targets predominantly occur in fibres of normal size and can therefore be regarded as manifestations of an early stage of denervation atrophy. The targetoid fibres, on the contrary, are of an atrophic size by 84%, while only a small population of about 15% contains targetoid fibres of a normal size on cross section.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00702673
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