ISSN:
1434-0879
Keywords:
Calcium oxalate
;
Glycosaminoglycans
;
Growth inhibitors
;
Proteins
;
Urine
;
Urine calculi
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary We have detected and isolated a macromolecular constituent in normal human urine possessing calcium crystal growth inhibitory activity. The purification procedure consisted of two anion exchange chromatographies and one affinity chromatography. The crystal growth inhibitor was found to be heterogeneous in net charge as well as in size. It has not been identified. It is not an uronic acid-containing glycosaminoglycan, hitherto presumed to be responsible for the inhibitory activity. Whether an urinary fragment of inter-α-trypsin inhibitor is responsible has yet to be resolved.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00297368
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