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  • 1990-1994  (16)
  • 1975-1979  (7)
  • 1
    Electronic Resource
    Electronic Resource
    Azetidinone antibiotics. XVI. Synthesis of 3-hydroxy-, 3-chloro-, and 3-methoxy-3-cephems from penicillins via 4-dithio-2-azetidinone intermediates (1976)
    s.l. : American Chemical Society
    The @journal of organic chemistry 41 (1976), S. 2276-2279 
    Details
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jo00875a013
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Evidence for coupling between hydrodynamic interactions and excluded volume effects in polymer coils (1990)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 92 (1990), S. 5731-5743 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: In a side-by-side comparison, the q dependence of the collective internal decay constant ∼(ΔΓ)∼qγ of linear polystyrene in good and theta solvents was determined using photon correlation spectroscopy. The results q2.9 and q3.9 for the theta and good solvents, respectively, correspond to relatively strong hydrodynamic interactions (nondraining) when excluded volume effects are minimal for the compact coil at theta and to relatively weak hydrodynamic interactions (partial draining) when excluded volume effects are manifest in the swollen coil in good solvent.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.458504
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  • 3
    Electronic Resource
    Electronic Resource
    Azetidinone antibiotics. XII. Chemical transformations of penicillins and cephalosporins. Mechanism and stereochemistry of the interconversions of penam and cepham systems (1975)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 97 (1975), S. 3192-3198 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00844a045
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Leucocytes and related cells in the plaice Pleuronectes platessa (1976)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish biology 8 (1976), S. 0 
    Details
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: The leucocytes and related cells of the blood of plaice were examined morphologically and their various functions assessed using a number of procedures to identify phagocytosis histochemical reactions and antibody responses. Four morphologically different types of thrombocytes were identified in addition to lymphocytes, plasma cells, monocytes, macrophages and one type of granulocyte which histochemically resembled the mammalian neutrophil. The evolution and development of the cells was also investigated and the various stages described.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1095-8649.1976.tb03928.x
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  • 5
    Electronic Resource
    Electronic Resource
    Defence mechanisms in fish (1976)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish biology 8 (1976), S. 0 
    Details
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: The lympho-reticular tissues in the plaice were investigated for their phagocytic properties on colloidal carbon after its intraperitoneal injection. Fish were killed at intervals ranging from 10 min to 25 days after injection. Although peritoneal macrophages constituted a large population of phagocytic cells, most of the carbon apparently gained access to the circulation as free particles and phagocytosis was performed predominantly by the ellipsoids of the spleen, the network of reticulo-endothelial (RE) cells throughout the haemopoietic tissue of the kidney, and by the RE cells occupying intermuscular spaces in the atrium of the heart. The cardiac macrophages rapidly emigrated from the organ while the carbon containing macrophages in the kidney and spleen formed aggregates in the lymphoid areas, either within or outwith pre-existing aggregates of melano-macrophages.The possible significance of phagocyte aggregations, including melano-macrophages, in association with lymphoid elements in the kidney and spleen is discussed in the context of immune mechanisms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1095-8649.1976.tb03908.x
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  • 6
    Electronic Resource
    Electronic Resource
    Abnormalities of differentiation and maturation in the oesophageal squamous epithelium of patients with tylosis: morphological features (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 19 (1991), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Tylosis is an autosomal dominant inherited defect of keratinization, associated in two Liverpool families with a high risk of eveloping oesophageal squamous carcinoma. In 29 individuals, followed by regular endoscopy and biopsy, we have noted several morphological abnormalities of the epithelium in this pre-cancerous condition. A control group of 43 non-tylotic patients with normal oesophageal histology and a further 26 patients with acute oesophagitis was used for comparison. Recognizable dysplasia was confined to the older age range in the tylotic group and was present in four patients. Almost half of the patients showed acute inflammation. Abnormalities of maturation were common, the most frequent being the presence of prominent basophilic inclusions and clear cell acanthosis, with parakeratosis and frank surface keratinization present in smaller numbers. There was, however, no statistically significant difference between the tylotic and inflamed control groups for any of these features. The only feature to show a significant difference between these groups was the presence of individual cell keratinization. The results suggest that in the oesophageal epithelium of the patients with tylosis, inflammation is the predominant abnormality, together with individual cell keratinization, and that these lesions appear in a much younger age group than dysplasia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1991.tb00044.x
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  • 7
    Electronic Resource
    Electronic Resource
    The leucocytes of fish: A review (1977)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish biology 11 (1977), S. 0 
    Details
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: The data available in the literature concerning fish thrombocytes, lymphocytes, monocytes, macrophages and granulocytes is discussed and the dearth of reliable information concerning the functional identity of most fish leucocytes is underlined. The methods of applying nomenclatures to fish leucocytes encountered in the literature is discussed in some detail and found to be unsatisfactory. An attempt is made to simplify the confused and conflicting reports by applying the concepts which have recently arisen in the field of mammalian immunology. Nomenclatures are assigned to cells on a functional and morphological basis where sufficient data exists.Thrombocytes are responsible for clot formation and are considered to be distinct, separate and unrelated to lymphocytes. Lymphocytes are recognised as immuno-competent cells though as yet little information exists on their role in immune mechanisms. Recent work is furnishing interesting results in this direction, especially in the origin of lymphocyte populations and their co-operative responses in immunity. Previous references to monocytes and macrophages in fish are confused and the literature is discussed in the light of the new classification of the Mononuclear Phagocyte System.Very few experimental data exist concerning granulocytic leucocytes in fish, indeed the presence of such cells with granulocytic functions still requires proof. Cells with morphological similarity to mammalian granulocytes do exist in fish but information essential for an understanding of their role in defence mechanisms is lacking. The state of the literature concerning the eosinophil, basophil and mast cell in fish is so confused that an entirely new approach to a study of these cells is warranted. It is hoped that this review will supply guidelines for future research.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1095-8649.1977.tb04140.x
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  • 8
    Electronic Resource
    Electronic Resource
    Novel cell types isolated from the skin of rainbow trout, Oncorhynchus mykiss (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish biology 42 (1993), S. 0 
    Details
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Cells were isolated from the skin of rainbow trout, Oncorhynchus mykiss, by collagenase digestion and were observed using light and electron microscopy. Four novel cell types were identified and are described herein.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1095-8649.1993.tb00330.x
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  • 9
    Electronic Resource
    Electronic Resource
    Utilization of haem compounds by Aeromonas salmonicida (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish diseases 17 (1994), S. 0 
    Details
    ISSN: 1365-2761
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Abstract. The ability of A-layer-positi ve (A+) and A-layer-negative (A−) strains of Aeromonas salmonicida to utilize haem sources of iron under conditions of iron-restriction was evaluated. In a plate bioassay, only A+ strains of A. salmonicida were able to utilize haem from a variety of sources including haem, haemin, myoglobin, haemoglobin, haemoglobin- haptoglobin and haem-albumin complexes. Trypsin-digestion of whole cells abolished haem- binding, indicating that binding was cell-surface associated, involving a protein binding site or receptor. Competitive binding studies indicated that all haem compounds were bound by a common receptor, which was not iron-regulated and was associated with the presence of the 49-kDa A-layer protein. The ability of both typical A+ (siderophore-positive) and atypical A+ (siderophore-negative) strains to utilize haem indicated that the mechanism of haem utilization was not siderophore-mediated and that A. salmonicida possesses both siderophore-dependent and siderophore-independent mechanisms to overcome iron-restricted conditions encountered in vivo.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2761.1994.tb00232.x
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  • 10
    Electronic Resource
    Electronic Resource
    Susceptibility of salmonid erythrocytes to lysis by bacterial lipopolysaccharides (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish diseases 14 (1991), S. 0 
    Details
    ISSN: 1365-2761
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Abstract. Bacterial lipopolysaccharide (LPS) is known to have binding affinity for mammalian erythrocyte membranes but does not cause haemolysis. In this study, LPS from eight different bacterial species all possessed haemolytic activity for salmonid erythrocytes. There were some differences in haemolytic activity among the different bacterial LPS after 2 h incubation. Lytic titres continued to increase with time for some LPS species reaching extremely high litres after 20 h incubation for the Salmonella minnesota LPS. The LPS extracted by the hot-phenol method from extracellular products (ECP) of Aeromonas salmonicida was more haemolytic than that extracted from the bacterial cell walls. Separated lipid A- and O-antigen fractions of A. salmonicida LPS had a similar low haemolytic activity. When A. salmonicida LPS, lipid A- and O-antigen were pre-incubated with bovine serum albumin, only LPS extracted from ECP retained any haemolytic activity. The LPS types used in this study were not haemolytic for rabbit erythrocytes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2761.1991.tb00598.x
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