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  • 1990-1994  (2)
  • 1975-1979  (2)
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  • 1
    Digitale Medien
    Digitale Medien
    Phosphatidylinositol Kinase Is Reduced in Alzheimer's Disease (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 58 (1992), S. 0 
    Details
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Abstract: Phosphatidylinositol (PI) kinase and PI phosphate (PIP) kinase activities were measured in postmortem samples of brain tissue from patients with Alzheimer's disease and nondemented control subjects. A membrane-free cytosolic fraction from four neocortical locations, with exogenous inositol lipids as the substrate, was used. Tissue from patients with Alzheimer's disease was characterized by reduced PIP formation; the reduction was 50% in prefrontal cortex, temporal cortex, and parietal cortex and 40% in precentral gyrus. In contrast, no alterations were found in PI bisphosphate formation in these four neocortical locations. The specific changes in PI kinase but not PIP kinase activity suggest that the findings may have functional relevance to the involvement of brain membrane processes in Alzheimer's disease.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-4159.1992.tb10981.x
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  • 2
    Digitale Medien
    Digitale Medien
    Phospholipid exchange proteins in synaptosome and myelin fraction from rat brain (1976)
    [s.l.] : Nature Publishing Group
    Nature 260 (1976), S. 354-355 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] Myelin and synaptosomes were prepared from rat brain cerebral hemispheres according to a slightly modified centrifugation scheme used by Morgan et al.9 (legend to Fig. 1). The myelin fraction consisted mainly of irregularly formed multilamellar structures of vesicular appearance, often enclosing ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/260354a0
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  • 3
    Digitale Medien
    Digitale Medien
    Structural data concerning reptilian (tortoise) egg lysozyme (1977)
    Springer
    Journal of molecular evolution 10 (1977), S. 261-264 
    Details
    ISSN: 1432-1432
    Schlagwort(e): Lysozyme ; Tortoise ; Evolution ; Reptile
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Summary A first series of structural studies allowed a reptilian egg-white lysozyme isolated fromTrionyx gangeticus to be classified among the c (chicken) type lysozymes
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01764601
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  • 4
    Digitale Medien
    Digitale Medien
    Tolerance for light and sound of patients with persistent post-concussional symptoms 6 months after mild head injury (1991)
    Springer
    Journal of neurology 238 (1991), S. 443-446 
    Details
    ISSN: 1432-1459
    Schlagwort(e): Light ; Sound ; Tolerance ; Post-concussional syndrome
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Patients with post-concussional symptoms (PCS) about 6 months after a mild head injury (MHI) were examined for tolerance of light and sound in comparison with concussed patients without PCS and nonconcussed healthy controls. MHI patients with PCS were individually matched with subjects from the two control groups for the time elapsed from the injury, and for age and sex. Using a computerized rating technique, we assessed both the maximal and submaximal levels of lowered tolerance for light and sound over a wide range of stimuli. We found that the MHI patients with PCS 6 months after the trauma (n=11) tolerated significantly less well stimuli of intensities of 71 dB and 500 lx than MHI patients without PCS (n=11) and non-concussed controls (n=11). There were no significant differences in tolerance for light and sound between MHI patients without PCS and the non-injured controls. Decreased tolerance for light and sound may contribute to the persistence of symptoms up to 6 months after a mild head injury. The psychophysical method provides an objective measure for the evaluation of the late persistent postconcussional syndrome.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00314651
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