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  • 1990-1994  (2)
  • 1975-1979  (3)
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Year
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of neurology 238 (1991), S. 315-319 
    ISSN: 1432-1459
    Keywords: Valproic acid ; Infants ; Protein binding ; Pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The pharmacokinetics of free and total valproic acid (VPA) in plasma and whole blood after oral administration during steady state was investigated in seven infants (mean age 10.7 months) receiving monotherapy. The VPA concentrations in whole blood closely followed those in plasma but at a reduced level. A positive correlation was found between dose and mean plasma concentration (r=0.71). Mean terminal half-lives were similar in plasma and whole blood (12.5 and 15.5 h, respectively), but were considerably longer than for free VPA (6.4 and 6.5 h, respectively; P〈0.01). There was a significant decrease in half-lives with increasing age (P〈0.05). Plasma and whole blood clearance for total VPA was higher than reported in older infants and adults (17.8 and 28.9 ml/kg per hour) and was considerably higher for free VPA (127.6 and 188.8 ml/kg per hour, respectively). The increase in clearance compared with that in older subjects is well in concordance with a lower protein binding of VPA (mean 85.3%). Of special importance is that the percentage of unbound VPA increased with increasing concentrations of total VPA. The fraction of unbound VPA in plasma increased even more in subjects with low albumin concentrations (P〈0.01).
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Flow, turbulence and combustion 33 (1977), S. 151-162 
    ISSN: 1573-1987
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract A lossless wave supporting system is modelled by two linear partial differential equations with variable coefficientsα(x) andβ(x),x≥0, which represent the distributed parameters of the system. The problem of determiningα(x) andβ(x) from measurements performed at the boundaryx=0 is considered. It is shown that generally it is only possible to determine an impedance function $$\bar Z$$ (ξ), where $$\bar Z$$ and ξ depend onα andβ. If some additional relationship is known betweenα andβ, however, it may be possible to fully determine these parameters. This is the case if, for example, it is known that the wave speed is constant. The results are interpreted for sample cases from solid mechanics, fluid mechanics, acoustics, and electromagnetic theory, and solutions are given of specific problems. The paper generalizes work on determination of vocal tract shapes from acoustical measurements made at the lips.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Experimental mechanics 17 (1977), S. 213-218 
    ISSN: 1741-2765
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract Provided that the one-dimensional wave equation applies, strain measurement at two sections of a linearly elastic cylindrical rod makes it possible to determine a number of important quantities at an arbitrary section of the rod; for example, strain, particle velocity and power transmission. The equations needed are derived, and the design of an analogue real-time analyzer is presented. The influence of some principal sources of error is analyzed and it is shown that it should be possible to perform accurate evaluation (errors less than a few percent) during a time interval which is not very long compared to the travelling time for a wave between the two gage positions. Comparisons are made between direct measurement and digital evaluation of strain, and between digital and analogue evaluation of particle velocity and power transmission. The discrepancies are typically less than ten percent during a time interval of 20 travelling times between gages. Although these results do not represent what is achievable, the accuracy is sufficient in several applications and demonstrates the feasibility of the method used.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Journal of elasticity 9 (1979), S. 197-200 
    ISSN: 1573-2681
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 36 (1990), S. 283-286 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
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