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  • 1990-1994  (2)
  • 1970-1974  (1)
  • 1960-1964
  • 1905-1909
  • 21.60.Ev  (1)
  • Artificial intelligence  (1)
  • Calcium  (1)
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  • 1990-1994  (2)
  • 1970-1974  (1)
  • 1960-1964
  • 1905-1909
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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Calcified tissue international 6 (1970), S. 103-112 
    ISSN: 1432-0827
    Keywords: Calcium ; Strontium ; Bone ; Exchange ; Equilibrium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Description / Table of Contents: Résumé La réactivité de l'os de rat envers un contenu faible et élevé de strontium a été étudiée par la technique de l'échange radioisotopique dans des conditionsin vitro bien définies. Des courbes d'absorption de solution de45Ca par des poudres d'os, pauvres et riches en strontium, ainsi que celles de solution de85Sr par des poudres d'os, riches en strontium, ont été analysées. Des fonctions exponentielles et de puissance ont été établies. Les résultats indiquent que le strontium en solution atteint un équilibre d'échange dans l'os, à contenu élevé en strontium, en huit heures environ et que le calcium continue à rechercher un état d'équilibre. Il semble, en outre, que les réactions de diffusion et d'échange de surface de la phase solide hydratée soient les mécanismes majeurs observés pendant ces expériences.
    Abstract: Zusammenfassung Die Reaktionsfähigkeit von Rattenknochen mit niederem und hohem Strontiumgehalt wurdein vitro mit der Isotopenaustauschtechnik unter gut definierten Bedingungen untersucht. Kurven, welche die vom Knochenpulver mit niederem und hohem Strontiumgehalt aufgenommene45Ca-Menge, sowie jene von Knochenpulver mit ausschließlich hohem Strontiumgehalt aufgenommene85Sr-Menge wiedergaben, wurden ausgewertet. Die Gleichungen der Exponential- sowie der Potenzfunktionen wurden abgeleitet. Die Interpretation der Ergebnisse dieser Experimente ist, daß das Strontium der Lösung ein Austauschgleichgewicht mit Knochen mit hohem Strontiumgehalt nach einer Periode von etwa 8 Std erreicht, während Calcium fortfährt, sich einem Gleichgewichtsstadium zu nähern. Es wird weiterhin vermutet, daß Diffusion und Oberflächen-Austauschreaktionen der Hydratationsschicht der soliden Phase die vorherrschenden Vorgänge sind, die im Laufe dieser Experimente stattfinden.
    Notes: Abstract The reactivity of rat bone of low- or of high-strontium content was investigated by the technique of radioisotopic exchange under well-defined conditionsin vitro. Analyses of curves depicting the uptake from solution of45Ca by low- and by high-strontium bone powders, and of85Sr by high-strontium bone powder only, were performed. Both exponential and power function expressions were derived. The interpretation of results of these experiments is that strontium of solution reaches exchange-equilibrium with bone of high-strontium content over a period of about eight hours, but that calcium continues to approach a state of equilibrium. Further, it is suggested that diffusion and surface exchange reactions of the hydrated solid phase are the dominant processes operating during the periods of these experiments.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of computer aided molecular design 7 (1993), S. 127-153 
    ISSN: 1573-4951
    Keywords: Artificial intelligence ; De novo design ; Molecule design ; Enzyme inhibitors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary SPROUT is a new computer program for constrained structure generation that is designed to generate molecules for a range of applications in molecular recognition. It uses artificial intelligence techniques to moderate the combinatorial explosion that is inherent in structure generation. The program is presented here for the design of enzyme inhibitors. Structure generation is divided into two phases: (i) primary structure generation to produce molecular graphs to fit the steric constraints; and (ii) secondary structure generation which is the process of introducing appropriate functionality to the graphs to produce molecules that satisfy the secondary constraints, e.g., electrostatics and hydrophobicity. Primary structure generation has been tested on two enzyme receptor sites; the p-amidino-phenyl-pyruvate binding site of trypsin and the acetyl pepstatin binding site of HIV-1 protease. The program successfully generates structures that resemble known substrates and, more importantly, the predictive power of the program has been demonstrated by its ability to suggest novel structures.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1434-601X
    Keywords: 21.60.Ev ; 29.30.Kv ; 27.70.+q
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract High spin states of175, 176Pt have been populated in144Sm(35Cl,pxn) reactions at beam energies of 175–185 MeV. In-beamγ-ray spectroscopic techniques using the ESSA30 spectrometer array were adopted. Levels up to spin 26 in176Pt and tentatively up to spin 45/2 in175Pt have been identified. The data are interpreted within the framework of Cranked Shell Model calculations using the deformed Woods-Saxon potential and including monopole pairing.
    Type of Medium: Electronic Resource
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