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  • 1
    Electronic Resource
    Electronic Resource
    Heterocyclen mit einem Azaallyl-System, 4. 5H-Dibenz[c,e]azepine mit Donor-Gruppen in 7-Stellung (1991)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 124 (1991), S. 2085-2090 
    Details
    ISSN: 0009-2940
    Keywords: 5H-Dibenz[c,e]azepines ; Imidates ; alkyl ; heterocyclic ; Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Heterocycles with an Azaallyl System, 4.  -  5H-Dibenz[c,e]azepines with Donor Groups at the 7-Position5H-Dibenz[c,e]azepines substituted with a methoxy (1) or methylthio group (10) at the 7-position have been synthesized from 6,7-dihydro-5H-dibenz[c,e]azepin-5-one (5) by regioselective O- or S-alkylation with methyl trifluoromethansulfonate and subsequent NH-deprotonation. According to the spectroscopic properties the semicyclic 7-membered alkyl imidates exist exclusively in the benzenoid 5H structure.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19911240934
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  • 2
    Electronic Resource
    Electronic Resource
    Transport Properties of H+-Selective Membranes Containing Amine-Derivative Ionophores and Mobile Sites (1993)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 76 (1993), S. 407-415 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Transport processes in plasticized PVC membranes containing the H+ chromoionophore ETH 5294 and additional tetraphenylborate-type mobile sites were analyzed by employing the potential-step method. Using chronoamperometry, impedance spectroscopy, and UV/VIS absorbance measurements, it is shown that the ionophore behaves as a carrier for protons, when the membranes are immersed between two aqueous solutions. It was possible to document the changes in the concentration profiles of both free ionophores and ionic species in some of the membranes. There is no evidence of proton hopping between the ionophores.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19930760124
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  • 3
    Electronic Resource
    Electronic Resource
    Untersuchungen zur Chemie von Isoindolen und Isoindoleninen, XXXVII. Symmetrisch substituierte 2-Alkyl-2H-isoindole (1990)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 123 (1990), S. 1719-1727 
    Details
    ISSN: 0009-2940
    Keywords: Isoindoles, symmetrically substituted ; Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Studies on the Chemistry of Isoindoles and Isoindolenines, XXXVII1) - Symmetrically Substituted 2-Alkyl-2H-isoindoles2-Alkyl-Rn-2H-isoindoles (1; Rn=4,5,6,7-tetramethyl, 4,5,6,7-tetrachloro) have been prepared efficiently by the N-oxide route and characterized by spectroscopic means.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19901230823
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  • 4
    Electronic Resource
    Electronic Resource
    Struktur und Reaktivität von isoanellierten heterocyclischen Systemen mit 4n;-π- und (4n + 2)-π-Elektronen, XVIII. Benzo[c]thiophene mit symmetrischer Struktur: Modifizierte und optimierte Herstellung nach der S-Oxid-Route (1991)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 124 (1991), S. 645-654 
    Details
    ISSN: 0009-2940
    Keywords: Benzo[c]thiophenes ; preparation by the S-oxide route ; Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Structure and Reactivity of Isoannullated Heterocyclic Systems with 4n;-π and (4n + 2)-π Electrons, XVIII. - Benzo[c]thiophenes with Symmetric Structure: Modified and Optimized Preparation by the S-Oxide RouteBenzo[c]thiophenes (15) with symmetric structure have been prepared efficiently from 1,3-dihydrobenzo[c]thiophene 2-oxides (9) by reaction with aluminium oxide, by O-acylation with trifluoroacetic anhydride, or O-alkylation with methyl trifluoromethanesulfonate. The aromatization of the S-oxides 9 is achieved by O-functionalization, subsequent elimination, and consecutive deprotonation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19911240332
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  • 5
    Electronic Resource
    Electronic Resource
    Untersuchungen zur Chemie von Isoindolen und Isoindoleninen, XXXIX. Reaktionen von 2-Alkyl-4,5,6,7-Rn-2H-isoindolen (Rn=tetramethyl, tetrachlor) mit aktivierten C=C-Dienophilen (1992)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 125 (1992), S. 183-189 
    Details
    ISSN: 0009-2940
    Keywords: 2H-Isoindoles, 2-alkyl-, reactions with C=C dienophiles ; Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Studies on the Chemistry of Isoindoles and Isoindolenines, XXXIX.  -  Reactions of 2-Alkyl-4,5,6,7-Rn-2H-isoindoles (Rn=tetramethyl, tetrachloro) with Activated C=C DienophilesSubstituted 2H-Isoindoles 2 react with maleic imides in absolute ether. Cycloaddition in 1,3-position leads to the formation of 1:1 adducts. The ratio between endo isomers 4 and exo isomers 5 depends on the substituents and the solvents. In the case of steric hindrance the Diels-Alder addition can be induced by Lewis acids. In the presence of oxygen-substituted 4,5,6,7-tetrachloro-2-methylisoindolin-1-ones 7 are formed as minor products.
    Additional Material: 6 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19921250130
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  • 6
    Electronic Resource
    Electronic Resource
    Untersuchungen zur Chemie von Isoindolen und Isoindoleninen, XXXVI1. Reaktionen von 2-Alkyl-2H-isoindolen mit Maleinimiden (1990)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 123 (1990), S. 381-390 
    Details
    ISSN: 0009-2940
    Keywords: o-Quinoid hetarenes / Isoindoles, cycloaddition reactions with / Dienophiles, CC ; Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Studies on the Chemistry of Isoindoles and Isoindolenines, XXXVI - Reactions of 2-Alkyl-2H-isoindoles with Maleic Imides2-Alkyl-2H-isoindoles 2 react with maleic imides 4 exclusively in position 1 and 3 by cycloaddition to form Diels-Alder adducts. The transformation of the endo isomers 6 into the thermodynamically more stable exo isomers 7 depends on the dienophile. The cycloaddition is useful for analytical detection of o-quinoid hetarenes 2 and for the synthesis of 7-azabicyclo[2.2.1]heptenes.
    Additional Material: 3 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19901230225
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  • 7
    Electronic Resource
    Electronic Resource
    Crystal structure of CTP-ligated T state aspartate transcarbamoylase at 2.5 Å resolution: Implications for ATCase mutants and the mechanism of negative cooperativity (1993)
    New York, NY : Wiley-Blackwell
    Proteins: Structure, Function, and Genetics 15 (1993), S. 147-176 
    Details
    ISSN: 0887-3585
    Keywords: X-ray crystallography ; pAR5 mutant ; allosteric enzyme ; ligand-induced negative cooperativity ; alternative amino acid conformations ; coordinate error ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The X-ray crystal structure of CTP-ligated T state aspartate transcarbamoylase has been refined to an R factor of 0.182 at 2.5 Å resolution using the computer program X-PLOR. The structure contains 81 sites for solvent and has rms deviations from ideality in bond lengths and bond angles of 0.018 Å and 3.722°, respectively. The cytosine base of CTP interacts with the main chain carbonyl oxygens of rTyr-89 and rIle-12, the main chain NH of rIle-12, and the amino group of rLys-60. The ribose hydroxyls form polar contacts with the amino group of rLys-60, a carboxylate oxygen of rAsp-19, and the main chain carbonyl oxygen of rVal-9. The phosphate oxygens of CTP interact with the amino group of rLys-94, the hydroxyl of rThr-82, and an imidazole nitrogen of rHis-20. Recent mutagenesis experiments evaluated in parallel with the structure reported here indicate that alterations in the hydrogen bonding environment of the side chain of rAsn-111 may be responsible for the homotropic behavior of the pAR5 mutant of ATCase. The location of the first seven residues of the regulatory chain has been identified for the first time in a refined ATCase crystal structure, and the proximity of this portion of the regulatory chain to the allosteric site suggests a potential role for these residues in nucleotide binding to the enzyme. Finally, a series of amino acid side chain rearrangements leading from the R1 CTP allosteric to the R6 CTP allosteric site has been identified which may constitute the molecular mechanism of distinct CTP binding sites on ATCase. © 1993 Wiley-Liss, Inc.
    Additional Material: 16 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prot.340150206
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  • 8
    Electronic Resource
    Electronic Resource
    Growth and analysis of crystal forms of toxic shock syndrome toxin 1 (1993)
    New York, NY : Wiley-Blackwell
    Proteins: Structure, Function, and Genetics 17 (1993), S. 329-334 
    Details
    ISSN: 0887-3585
    Keywords: bacterial toxins ; superantigens ; X-ray crystallography ; crystallization ; Staphylococcus aureus ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Native toxic shock syndrom toxin 1 (TSST-1) purified from Staphylococcus aurius has been crystallized in four different forms. The highest resolution data (2.05 Å) was collected from orthorhombic crystals belonging to the space group C2221. The unit cell dimension are a = 108.7 Å, b = 177.5 Å, c = 97.6 Å. Rotation function analysis of this from indicates that there is trimer of toxin molecules in the asymmetric unit with a local 3-fold axis parallel to the crystallographic c axis. Crystals of a double mutant of TSST-1 have been grown which has a single molecule in the asymmetric unit and diffract to 1.9 Å. The space group is P21 with unit cell parameters of a = 44.4 Å, b = 34.0 Å, c = 55.2 Å, β = 93.0°. © 1993 Wiley-Liss, Inc.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prot.340170310
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  • 9
    Electronic Resource
    Electronic Resource
    Physics of polymer surfaces and interfaces. Edited by Isaac C. Sanchez, Butterworth-Heinemann, 1992, 336 pp. (1994)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 40 (1994), S. 1088-1089 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690400623
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  • 10
    Electronic Resource
    Electronic Resource
    LCEC of underivatized polypeptides and proteins at copper electrodes (1992)
    Weinheim : Wiley-Blackwell
    Electroanalysis 4 (1992), S. 393-401 
    Details
    ISSN: 1040-0397
    Keywords: Proteins ; polypeptides ; amperometric detection ; liquid chromatography ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Constant potential amperometric detection of underivatized polypeptides and proteins can be carried out at metallic copper electrodes. When coupled with liquid chromatography, this approach provides a sensitive and selective method of analysis for these compounds. Two different detection mechanisms can be employed: a neutral pH, low potential oxidation process attributed to enhanced dissolution of the electrode by peptide species capable of forming soluble Cu(II) complexes and a high pH, high potential electrocatalytic oxidation of the analytes. Of the two approaches, the latter process was found to be more attractive for LCEC applications as it was useful for a wider range of peptides and proteins and gave substantially larger currents and lower detection limits. The compounds exhibiting useful electrocatalytic response at the copper electrode ranged from oligopeptides such as enkephalins and bradykinin to very large proteins such as glucose oxidase (F.W. 160,000) and catalase (F.W. 240,000). The response was not dependent on the presence of tyrosine, tryptophan, or cysteine amino acid units and was shown to be compatible with both ion-exchange and reverse-phase separation schemes.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/elan.1140040406
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