ISSN:
1432-2072
Keywords:
Chlorpromazine
;
7-Hydroxychlorpromazine
;
Chlorpromazine Sulphoxide
;
Clinical Response
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Eight male adult schizophrenic patients undergoing chronic treatment with chlorpromazine were investigated. Clinical assessments were made weekly by a psychiatrist who was unaware of the biochemical findings. Blood samples were drawn 3 h after the first daily dose and the plasma concentrations of chlorpromazine and 11 of its metabolites were assessed by a direct scan technique employing quantitative thin layer chromatography. Patients that responded well to treatment had high plasma levels of chlorpromazine and 7-hydroxychlorpromazine; whereas non-responders had high plasma levels of chlorpromazine sulphoxide. These preliminary findings support the hypothesis that chlorpromazine metabolites play an important role in determining clinical response to treatment, which arose from the failure of previous investigators to show a statistically significant relationship between plasma levels of the parent compound and clinical response.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00422150
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