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  • 1990-1994  (2)
  • 1970-1974
  • Brandopfer  (1)
  • Experimental allergic encephalitis  (1)
  • 1
    ISSN: 1432-0533
    Keywords: Major histocompatibility complex class II ; Wallerian degeneration ; Microglia ; Autoimmune disease ; Experimental allergic encephalitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To clarify the implication of the major histocompatibility complex class II (Ia) antigen induction in microglia following Wallerian degeneration in the central nervous system (CNS), experimental allergic encephalitis (EAE) was adoptively transferred to Lewis rats in which Ia antigens had been induced in microglia at the sites of Wallerian degeneration. In addition to randomly distributed typical EAE lesions, the recipient rats developed distinct inflammatory lesions in accord with the distribution of Ia-positive microglia; i.e., in the ipsilateral thalamus after cortical cryoinjury, and in the ipsilateral optic nerve, the contralateral optic tract and superior colliculus after unilateral eye ball enucleation. Thus, the EAE locus may be targeted by this approach. The inflammatory response was inducible by transfer of myelin basic protein-stimulated lymphocytes but not by transfer of phytohemagglutinin-stimulated or non-stimulated lymphocytes. When examined using monoclonal antibody surface markers; OX-6 for Ia antigen, W3/13 for pan T lymphocyte and OX-8 for cytotoxic/suppresser T lymphocyte, the types of lymphocytes in these lesions did not differ from those in ordinary EAE lesions in the spinal cord. The potential role of non-immunologically induced Ia-positive cell clusters that serve as a target for autoimmune CNS diseases was discussed.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    International journal of legal medicine 105 (1992), S. 65-68 
    ISSN: 1437-1596
    Keywords: Fire victim ; Exposure before or after death ; Carbon monoxide hemoglobin ; Gas chromatography ; Brandopfer ; Antemortale und postmortale Exposition ; Kohlenmonoxid-Hämoglobin ; Gaschromatographie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Description / Table of Contents: Zusammenfassung Mit Hilfe der Gaschromatographie wurde die Kohlenmonoxid-Konzentration im Blut des rechten und linken Herzens vergleichend untersucht. Das Material stammt von Leichen mit antemortaler oder nicht-antemortaler Feuer- oder CO-Exposition. Das Konzentrationsverhältnis von COHb zwischen linkem und rechtem Herzblut (L/R-Quotient) scheint ein nicht brauchbares Kriterium zu sein, um festzustellen, ob der Tod sich vor oder nach der Feuer-Exposition ereignet hat; mit der Ausnahme von solchen Fällen, wo bei makrokopischer Untersuchung kein Ruß in den Atemwegen gefunden wird und wo die COHb-Konzentration innerhalb jener Grenzen ist, welche für Zigaretten-Raucher als normal angesehen werden.
    Notes: Summary Carbon monoxide hemoglobin (COHb) concentrations in left and right heart blood samples from cadavers both exposed and not exposed to fire or CO gas were analyzed by the gas chromatographic method. The COHb concentration ratio between samples of left and right heart blood (L/R ratio) does not appear to be useful for establishing whether death has occurred before or after exposure to fire with the exception of cases where no soot can be detected in the airways by the naked eye and the COHb concentration in the blood sample is within the level considered normal for tobacco smokers.
    Type of Medium: Electronic Resource
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