Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Subterminal motor nerve abnormalities in psychotic patients (1974)
    [s.l.] : Nature Publishing Group
    Nature 249 (1974), S. 373-375 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] We now report neurological abnormalities of subterminal motor axons in 21 out of 29 psychotic patients. Our subjects were 16 acute and three chronic schizophrenics, one patient with a paranoid psychosis, four manic-depressives-manic or hypomanic phase-five psychotic depressives and two nonpsychotic ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/249373a0
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Rigidity, hyperpyrexia and coma following fluphenazine enanthate (1973)
    Springer
    Psychopharmacology 29 (1973), S. 337-346 
    Details
    ISSN: 1432-2072
    Keywords: Fluphenazine Enanthate ; Coma ; Extrapyramidal ; Creatine Phosphokinase ; Hypothalmus ; Neuroleptic “Malignant” Syndrome ; Muscular Figidity ; “Lethal Catatonia” ; Hyperpyrexia ; Malignant Hyperpyrexia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Beginning one day after receiving fluphenazine enanthate (Prolixin Enanthate®), 25 mg, subcutaneously, an acute schizophrenic girl with mixed schizoaffective and excited catatonic symptomatology became mute and withdrawn, then developed severe muscular rigidity and hyperpyrexia, and finally became comatose. The patient developed large increases in serum creatine phosphokinase (CPK) activity by the third day of this syndrome. The previously described symptoms, which have been labeled the neuroloptic “malignant” syndrome (Delay and Deniker, 1968), diminished with supportive treatment and intravenous benztropine mesylate (Cogentin®). Because of renewed psychotic behavior, phenothiazine treatment was eventually restarted, including treatment with fluphenazine enanthate, without recurrence of the extrapyramidal or hypothalamic symptoms. The difficulty in distinguishing between the neuroleptic “malignant” syndrome and Stauder's “acute lethal catatonia” is emphasized. The relationship between these syndromes and malignant hyperpyrexia is discussed. Possible causes of the increased serum CPK activity are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00429281
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Effects of phencyclidine and stress on plasma creatine phosphokinase (CPK) and aldolase activities in man (1972)
    Springer
    Psychopharmacology 26 (1972), S. 44-53 
    Details
    ISSN: 1432-2072
    Keywords: Phencyclidine ; Stress ; Creatine Phosphokinase ; Aldolase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Phencyclidine (Sernyl, Phen) is a potent psychotomimetic drug in man. In conjunction with restraint stress, Phen produces increased plasma creatine phosphokinase (CPK) and aldolase (Ald) activities and skeletal muscle pathology in rats. Increased plasma CPK and Ald activities and skeletal muscle pathology are found in some acutely psychotic patients. It was therefore of interest to determine if Phen increased plasma CPK or Ald levels in man. Four of seven subjects had no elevations of plasma CPK or Ald activity either before or after Phen, 0.1 mg/kg, i.v. One subject had increased CPK levels which began 1 h after Phen. Two subjects had increased Ald and/or CPK levels which began within 24 h before Phen administration and which persisted or increased for at least 24 h after Phen. The plasma enzyme changes occurred in those subjects who showed the most pronounced cognitive disruption after Phen. The effects of stress and Phen on plasma CPK and Ald levels and its implications for the study of muscle abnormalities in psychotic patients are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00421917
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Serotonergic measures in suicide brain: 5-HT1A binding sites in frontal cortex of suicide victims (1991)
    Springer
    Journal of neural transmission 85 (1991), S. 181-194 
    Details
    ISSN: 1435-1463
    Keywords: Serotonin1A (5-HT1A) receptor ; brain ; suicide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The density of 5-HT1A binding using3H-8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) as binding ligand, was studied in human frontal cortex of suicide victims and normal controls who died due to medical disease or accidentally. There was no difference in the maximum number of binding site (Bmax) or Kd (an inverse measure of affinity) of 5-HT1A receptor binding sites between normal controls and the entire group of suicide victims. However, nonviolent suicides had significantly higher Bmax (22—25%) compared to both controls and violent suicides. A negative correlation between age and Bmax of 5-HT1A binding sites was found in male controls but not in female controls or suicide victims. This relationship was less apparent among the male controls over age 60.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01244944
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Buspirone does not produce a 5-HT1A-mediated decrease in temperature in man (1991)
    Springer
    Journal of neural transmission 86 (1991), S. 71-76 
    Details
    ISSN: 1435-1463
    Keywords: Buspirone ; 5-HT1A receptor ; DA2 receptor ; body temperature
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Buspirone, a putative serotonin (5-HT)1A partial agonist, did not produce hypothermia in 17 normal volunteers in a placebo controlled, single blind study. Thus, buspirone may be a weaker agonist at those 5-HT1A receptors which mediate hypothermia compared to ipsapirone or gepirone, two other 5-HT1A partial agonists which have been reported to produce hypothermia by a 5-HT1A-mediated mechanism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01250377
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Serotonin2 (5-HT2) receptor binding in the frontal cortex of schizophrenic patients (1991)
    Springer
    Journal of neural transmission 85 (1991), S. 19-29 
    Details
    ISSN: 1435-1463
    Keywords: 5-HT2 receptor ; human postmortem brain ; schizophrenia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Serotonin2 (5-HT2) receptor binding was studied, using3H-spiperone as the ligand, in post-mortem brain specimens obtained from schizophrenic patients (N=11) and non-psychiatric controls (N=11). The maximum number of binding sites (Bmax) was significantly decreased in schizophrenic patients as compared to normal controls. This difference did not appear to be due to neuroleptic treatment. No difference in Kd (an inverse measure of the affinity of3H-spiperone to its binding sites) was observed between the two groups. However, studies with unmedicated schizophrenic patients are needed to draw any definite conclusion. The role of serotonergic processes in the psychobiology of schizophrenia is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01244654
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...