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  • 1990-1994  (3)
  • 1970-1974  (1)
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  • 1
    Electronic Resource
    Electronic Resource
    Lack of dose-response effect of terfenadine on resting bronchomotor tone in patients with asthma (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 21 (1991), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Bronchodilatation data from three, four-period cross-over studies were combined to assess the effect of oral terfenadine 60, 120, 180 mg and placebo on the airways of 26 patients with atopic asthma. Mela-analysis of these data showed that mean changes in FEY1 from pre-dose to 4 hr were 11.4, 14.6 and 11.8% for the three doses of terfenadine, respectively, and −2.9% for placebo. There was a significant treatment effect (P= 0.0001) but no effect of dose. Terfenadine, a non-sedating histamine H1-receptor antagonist, caused bronchodilatation in a single dose. Whether this efTect is sustained with long-term treatment requires further investigation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1991.tb01669.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of cetirizine, a potent H1 antagonist, on platelet activating factor induced bronchoconstriction in asthma (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 23 (1993), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Effect of eetirizine. a potent and specific H1 receptor antagonist, was examined on platelet activating factor-induced bronchoconstrietion in 10 patients (5 male, mean [s.e.m.] aged 37 4 [3–6] years) with mild asthma in a placebo controlled, double-blind cross-over study. Airway responses were assessed by measuring specific airway conductance (SGaw). Patients were challenged with a single dose (12–96 μG) of PAF that had previously produced a 35% fall in SGaw. PAF challenges were performed after single dose (15 mg) and I week's treatment (15mg twice daily) of cetirizine. There was no significant difference in pre-and post-treatment baseline values of SGaw on different study days and the percentage changes after cetirizine were 38 7 (701) and 45–6 (5–52) eompared to 50 2 (2–89) and 43–9 (7–26) with placebo respectively. Similarly mean (s.e.m.) area under eurve (AUC-SGaw/time course response) was 391 (143) and 514 (85) with cetirizine compared to 565 (37) and 461 (94) with placebo respectively. The difference was not statistically significant. There was no difference in facial flushing and feeling of warmth between cetirizine and placebo. We conclude that PAF induced bronehoconstriction in humans is not mediated by histamine release and that H1 receptor antagonists do not modify PAF indueed bronehoeonstriction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1993.tb03241.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Effect of oral and inhaled cetirizine in allergen induced bronchoconstriction (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 23 (1993), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Cetirizine is a potent, selective H1 histamine receptor antagonist. The effect of oral and inhaled eetirizine was assessed on the early bronchoconstrictor response to inhaled allergen in 10 mild atopie asthmatic patients in a double-blind, randomized, plaeebo controlled trial. All were sensitive to Dermatophagoides pleronyssinus and this was used as the provoking allergen. The geometric mean PD20 FEV] values obtained at allergen challenge were measured as cumulative breath units (c.b.u.) and following oral cetirizine, inhaled cetirizine and placebo were 124–5, 75–7 and 76–7 c.b.u. respectively. These did not differ significantly. We conclude that neither oral nor inhaled cetirizine significantly attenuates the early response to inhaled allergen in atopie asthmatic subjects. However, the method of repeated allergen challenge is likely to be relatively insensitive. Clinical and Experimental Allergy, [o]. 23, pp. 528–531.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1993.tb03242.x
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    The airways response to phenylephrine after blockade of alpha and beta receptors in extrinsic bronchial asthma (1973)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 3 (1973), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Phenylephrine, a powerful alpha receptor stimulant, has been shown to cause a significant fall in the FEV1 and SGaw in six patients with extrinsic bronchial asthma after prior beta blockade with propranolol. In contrast, propranolol or phenylephrine after prior beta blockade failed to effect a significant change in the FEV1 and SGaw in five normal subjects. The phenylephrine effect can be completely inhibited by alpha receptor blocking drugs, phenoxybenzamine and thymoxamine. These observations suggest that the bronchomotor tone in asthma is largely controlled by the sympathetic activity and that there are alpha receptors in the human airways which in the presence of beta blockade can be stimulated to give bronchoconstriction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1973.tb01351.x
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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