ISSN:
1432-0533
Keywords:
Key words Extraskeletal osteosarcoma
;
Brain neoplasms
;
Ultrastructure
;
Multinucleated giant cells
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract A 57-year-old woman with primary intracerebral osteosarcoma is reported. The tumor was identified by computed tomography as a mass with hemorrhage in the right parietal lobe. The surgical and pathological examinations confirmed an osteosarcoma of intracerebral origin. She suffered from repeated local recurrence of the tumor and died about 1 year after the onset. The pathological findings showed features of osteoblastic osteosarcoma with numerous osteoclast-like multinucleated giant cells. Immunohistochemically, tumor cells were positive for vimentin, and partially for actin. Multinucleated giant cells were reactive with vimentin and CD68 antibodies. Ultrastructurally, tumor cells were rich with rough endoplasmic reticulum. These findings are consistent with the histological features of skeletal or extraskeletal osteosarcoma. This is the third case of primary intracerebral osteosarcoma reported in the literature and the first one analyzed ultrastructurally.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00310384
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