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  • 11
    Electronic Resource
    Electronic Resource
    Springer
    Surgical endoscopy and other interventional techniques 8 (1994), S. 90-96 
    ISSN: 1432-2218
    Keywords: Pain ; Laparoscopic cholecystectomy ; Predictors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract It is postulated that laparoscopic cholecystectomy as “patient-friendly surgery” leads to more comfort and in particular to less pain. A prospective study on pain was performed on all patients undergoing the operation over the period of 1 year (n=382) out of a series of more than 1,000 patients who have undergone the operation in our clinic. Pain was measured by a 100-point visual analogue scale (VAS), by a five-point verbal rating scale, and by the consumption of analgesics. Pain was the most frequent symptom, both before and after the operation. The mean level of pain was 37 VAS points 5 h after the operation and declined to 16 points on the third day. In 106 patients (27.8%) the intensity of pain was higher than 50 VAS points. Analgesics were used by 282 patients (73.8%), opioids by 112 (29.3%). Pain was significantly higher in female than male patients (P〈0.05), but consumption of analgesics was similar in both groups. The most severe pain was localized to the abdominal wall wounds by 157 (41.1%) and to the right upper abdomen by 138 patients (36.1%) on the first postoperative day. Patients who needed opioids and/or had a pain level of 〉50 VAS points (n=138) had higher preoperative pain levels (P=0.018) and preoperatively complained more frequently about nausea, vomiting, bloating, and a feeling of abdominal pressure (P=0.003–0.031). However, predictive values of these variables were too small to be of clinical benefit. The duration of operation, intraoperative events (loss of bile, blood, or gallstones), and additional laparoscopic procedures (adhesiolysis, lavage, extension of an incision, suture of fascia) did not influence the intensity of postoperative pain. We conclude that laparoscopic cholecystectomy did cause significant postoperative pain in one-third of our patients only up to the first postoperative day. As predictors for high intensity of pain were not identified, pain should be monitored and analgesics should be delivered liberally.
    Type of Medium: Electronic Resource
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  • 12
    ISSN: 1437-160X
    Keywords: Active center analogues of superoxide dismutase ; Collagen type II-induced arthritis ; Potassium peroxochromate arthritis ; Autoimmunity ; Chemiluminescence ; Inhibition of tumor necrosis factor alpha ; Reactive oxygen species
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The anti-arthritic and anti-inflammatory efficacy of CuPu(Py)2 {[N, N′-bis(2-pyridylmethylene)-1,4-butanediamine] (N, N′, N″, N‴)}-Cu(II), a serum-stable active center analogue of Cu2Zn2-superoxide dismutase (SOD; EC 1.15.1.1), was tested in male DBA/1xB10A (4R) mice suffering from potassium-peroxochromate-induced (PIA) or collagen type II-induced arthritis (CIA). Parameters including the arthritis index, the plasma SOD activity, and the inhibition of phagocytic responses in unseparated blood were used for the assessment of disease activity. A dose-dependent suppression of arthritis was noted in both models. The ED50 was 2.5±0.4 μmol/kg/day of CuPu(Py)2 for PIA and 4.0±1.1 μmol/kg/day for CIA. The arthritis index correlated with both the levels of reactive oxygen species (ROS) generated by phorbol ester-activated neutrophils and monocytes in unseparated blood (r=0.892) and the SOD-like activity in plasma (r=0.857). CuPu(Py)2 inhibited also the lipoplysaccharide-induced release of tumor necrosis factor alpha from human monocytes and neutrophils in a dose-dependent manner. Unlike SOD, which exerts successful anti-rheumatic activity mainly upon intra-articular injection, the SOD-mimic CuPu(Py)2 can be applied systemically. Non-proteinaceous low molecular weight antioxidases may well be suited to control oxidative stress-derived damage in rheumatic diseases by modulation of ROS-dependent signal transduction pathways.
    Type of Medium: Electronic Resource
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  • 13
    Electronic Resource
    Electronic Resource
    Springer
    International journal of legal medicine 62 (1968), S. 173-173 
    ISSN: 1437-1596
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Type of Medium: Electronic Resource
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  • 14
    Electronic Resource
    Electronic Resource
    Springer
    International journal of legal medicine 63 (1968), S. 111-113 
    ISSN: 1437-1596
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Description / Table of Contents: Summary It was demonstrated on the basis of an incompatible mother-child pair that in the white population, too, Hp° must be supposed to appear. The case was observed among more than 4,000 mother-child pairs which were inconspicuous.
    Notes: Zusammenfassung Es wird über eine inkompatible Mutter-Kind-Paarung (Mutter Hp 1-1, Kind Hp 2-2) berichtet, wobei normale Typen festgestellt wurden. Eine Kindesvertauschung wurde durch Einbeziehung eventueller für die Vertauschung in Frage kommender Probanden ausgeschlossen.
    Type of Medium: Electronic Resource
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  • 15
    Electronic Resource
    Electronic Resource
    Springer
    Naturwissenschaften 80 (1993), S. 470-472 
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 16
    ISSN: 1573-5028
    Keywords: plant mitochondrial genome ; potato ; tRNAf Met ; tRNA pseudogene
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The initiator methionine transfer RNA (tRNAf Met) gene was identified on a 347 bpEco RI-Hind III DNA fragment of the potato mitochondrial (mt) genome. The sequence of this gene shows 1 to 7 nucleotide differences with the other plant mt tRNAsf Met or tRNAf Met genes studied so far. Whereas the tRNAf Met gene is present as a single copy in the potato mt genome, a tRNA ‘pseudogene’ corresponding to 60% of a complete tRNA (from the 5′ end to the variable region) and located at 105 nucleotides upstream of the tRNAf Met gene on the opposite strand was shown to be repeated at least three times. Furthermore, the physical environment of the tRNAf Met gene in the mt genome is very different among plants, which suggests that the tRNAf Met gene region has often been implicated in recombination events of plant mt genomes leading to important rearrangements in gene order.
    Type of Medium: Electronic Resource
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  • 17
    Electronic Resource
    Electronic Resource
    Springer
    Virchows Archiv 275 (1930), S. 397-407 
    ISSN: 1432-2307
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Bei einem Kind mit angeborener Knochenbrüchigkeit (Ost. imp.), das klinisch alle typischen Veränderungen darbot, war eine Besserung der Knochenbeschaffenheit festzustellen, vor allem waren Knochenbrüche ausgeblieben und das Schädeldach fester geworden. Das Kind hatte gleich nach der Geburt Vigantol erhalten und später eine längere Vigantolbehandlung durchgemacht, allerdings ohne wesentliche Beeinflussung des P.- und Ca-Spiegels im Blut. Nachdem es 101/2 Monate alt an Bronchopneumonie gestorben war, ergab die pathologisch-anatomische Untersuchung noch die Kennzeichen der Ost. imp. Mangelhaft war die enchondrale Verknöcherung an den Gliedmaßen und Rippen, weitgehend vorgeschritten aber die periostale Knochenbildung mit Zeichen frischer Anbildung. Vor allem ließen aber die Schädelknochen lebhafte frische Knochenanbildung nach dem Typus der primären Knochenbildung erkennen. Ob diese Besserungserscheinungen als Vigantolwirkung aufzufassen sind, muß dahingestellt bleiben.
    Type of Medium: Electronic Resource
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  • 18
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 17 (1994), S. 109-115 
    ISSN: 0935-6304
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 19
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 17 (1994), S. 169-173 
    ISSN: 0935-6304
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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