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  • 1990-1994  (3)
  • 1965-1969
  • Ascorbate  (1)
  • Characterization  (1)
  • DNA methylation  (1)
Materialart
Erscheinungszeitraum
  • 1990-1994  (3)
  • 1965-1969
Jahr
  • 1
    Digitale Medien
    Digitale Medien
    Springer
    Annals of the Institute of Statistical Mathematics 46 (1994), S. 351-360 
    ISSN: 1572-9052
    Schlagwort(e): Characterization ; exponential distribution ; gamma distribution ; geometric distribution ; Poisson process ; renewal process
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Mathematik
    Notizen: Abstract Given two independent positive random variables, under some minor conditions, it is known that fromE(Xr∥X+Y)=a(X+Y)r andE(Xs∥X+Y)=b(X+Y)s, for certain pairs ofr ands, wherea andb are two constants, we can characterizeX andY to have gamma distributions. Inspired by this, in this article we will characterize the Poisson process among the class of renewal processes via two conditional moments. More precisely, let {A(t), t≥0} be a renewal process, with {S k, k≥1} the sequence of arrival times, andF the common distribution function of the inter-arrival times. We prove that for some fixedn andk, k≤n, ifE(S k r ∥A(t)=n)=atr andE(S k s ∥A(t)=n)=bts, for certain pairs ofr ands, wherea andb are independent oft, then {A(t), t≥0} has to be a Poisson process. We also give some corresponding results about characterizingFto be geometric whenF is discrete.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Springer
    Archives of toxicology 66 (1992), S. 646-651 
    ISSN: 1432-0738
    Schlagwort(e): Sodium dichromate ; Nephrotoxicity ; Glutathione ; Ascorbate ; Carbohydrate metabolism
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Ascorbate treatment 30 min prior to sodium dichromate (20 or 30 mg/kg, s.c.) shows higher potency than that of glutathione (GSH) in protecting against both the metabolic disturbance and nephrotoxicity induced by dichromate. However, ascorbate treatment after 2 h of dichromate intoxication had no effect on dichromate-induced blood urea nitrogen (BUN) elevation 3 days after intoxication. In contrast, dichromate-induced glucosuria, which reached maximum levels at 3 days after treatment, was significantly decreased by GSH or N-acetyl cysteine (NAC) treatment, even if its administration was after 24 h of dichromate intoxication. Pretreatment with GSH depletors such as diethyl maleate (DEM) and buthionine sulfoximine (BSO) had no effect on dichromate-induced nephrotoxicity. GSH levels in the liver and kidney were not affected at 3 h after dichromate treatment. However, dichromate significantly increased tissue GSH levels with a marked increase in liver per kidney GSH ratio at 24 h after treatment, if food was withheld subsequent to dichromate treatment, indicating that GSH biosynthesis resulted from the accelerated protein breakdown. These results suggest that GSH-mediated dichromate reduction is not a kinetically favorable pathway in vivo; however, GSH plays an important role in protection against dichromate-induced nephrotoxicity. In addition, the cellular metabolism of dichromate in the early period after treatment is important in the pathogenesis of its nephrotoxicity.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    ISSN: 1058-8388
    Schlagwort(e): CRABP-I ; P19 cells ; DNA methylation ; Gene expression ; Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: The mouse cellular retinoic acid binding protein-I (CRABP-I) gene is specifically up-regulated by retinoic acid (RA) in P19 mouse embryonal carcinoma cells, and its expression in animals is spatially and temporally restricted to RA-sensitive tissues during embryonic development. This study demonstrates that, in adult mouse tissues and P19 cells where the expression of CRABP-I is detected at the basal level, the 5′- flanking region of the CRABP-I gene is hypermethylated at the C residues of all the Hpa II sites. Conversely, in mouse embryos during early stages of development when the expression of CRABP-I gene is detected at a much higher level, this region is demethylated at these Hpa II sites. In P19, enhancement on the RA-induced up-regulation of CRABP-I can be observed in cells treated with 5-azacytidine (5-AzaC) in conjunction with RA, where partial demethylation in the 5′-flanking region of CRABP-I gene is observed. Nuclear run-on experiments indicate that increased message levels of CRABP-I in P19 cells can be accounted for, at least partially, by increases in its transcription rates. The induction of retinoic acid receptor (RAR) β by RA can also be enhanced by 5-AzaC, but to a much lesser degree. In contrast, all the Hpa II sites in the structural gene portion, at least in the first two exons, are fully demethylated at the C residues. © 1994 Wiley-Liss, Inc.
    Zusätzliches Material: 9 Ill.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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