ISSN:
1573-2568
Keywords:
cysteamine
;
somatostatin
;
insulin
;
exocrine pancreas
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Cysteamine is known to deplete somatostatin from pancreatic D cells. In the isolated perfused rat pancreas we investigated its effects on somatostatin and insulin release as well as exocrine pancreatic secretion in the presence of 16.7 mM glucose and 180 pM CCK-8. At a concentration of 0.1 mM, cysteamine had no significant effect on pancreatic endocrine and exocrine functions. At 10 mM, however, cysteamine released somatostatin (380±70 vs 100±20 fmol/20 min), inhibited insulin output (890±120 vs 13210±3260 μunits/20 min) and reduced exocrine pancreatic secretion (volume: 12±2 vs 20±2 μl/20 min; lipase: 31±3 vs 60±7 units/20 min). We conclude that the complex changes induced by cysteamine are consistent with a physiological role of endogenous somatostatin in the regulation of insulin release. The reduction of exocrine pancreatic secretion, however, was at least in part, if not completely, mediated via the insuloacinar axis rather than a direct effect of cysteamine-released somatostatin on pancreatic acinar cells.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01296769
Permalink
