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  • 1990-1994  (2)
  • 1950-1954
  • Cryptomonas  (1)
  • Key words Disposition  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Cancer chemotherapy and pharmacology 35 (1994), S. 89-92 
    ISSN: 1432-0843
    Keywords: Key words Disposition ; 7-Hydroxystaurosporine ; Protein kinase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  UCN-01, a hydroxylated derivative of staurosporine, was selected for study because of its promising antitumor activity. For mice dosed intravenously, subcutaneously, or by oral gavage with this compound, the maximum tolerated doses (MTD) were 20, 10, and 〉100 mg/kg, respectively. UCN-01 was stable in mouse and dog plasma, but in human plasma it was converted to a metabolite in a process not inhibited by standard protease and esterase inhibitors. Following an intravenous dose of 10 mg/kg UCN-01, the half-lives for the initial (t 1/2α) and terminal (t 1/2β) exponential phases of elimination were 10 and 85 min, respectively; the area under the plasma concentration-time curve (AUC value) was 117 μg min ml–1. In mice dosed by oral gavage with 10 mg/kg, the calculated value for the half-life of the elimination phase was 150 min. The AUC value was 15 μg min ml–1, giving a value for bioavailability of 13%. After subcutaneous dosing with 10 mg/kg, the calculated values for half-lives for the distribution and elimination phases were 23 and 130 min, respectively; the AUC value was 113 μg min ml–1. Since this value is equivalent to that obtained for intravenous dosing, administration of UCN-01 by the subcutaneous route may be an alternative to intravenous dosing in preclinical and clinical trials.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1615-6102
    Keywords: Basal bodies ; Cell symmetry ; Cryptomonas ; Cryptophyceae ; Flagellar apparatus ; Flagellar transformation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary InCryptomonas ovata, long, dorsal flagella are produced which transform during the following cell division into short, ventral flagella. At division there is a reorientation in cell polarity, and the parental basal apparatus, which comprises the basal bodies and associated roots, is distributed to the daughter cells via a complex sequence of events. Flagellar apparatus development includes the transformation of a four-stranded microtubular root into a mature root of different structure and function. Each newly formed basal body nucleates new microtubular roots, but receives a striated fibrous root from a parental basal body. The striated roots are originally produced on the transforming basal body and are “transferred” to the new basal bodies at each successive division. The development of the asymmetric flagellar apparatus throughout the cell cycle is described.
    Type of Medium: Electronic Resource
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