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The distribution and possible function of gamma interferon-immunoreactive cells in normal endometrium and myometrium (1992)

Stewart, Colin J. R. ; Farquharson, Maura A. ; Foulis, Alan K.

Springer

Virchows Archiv 420 (1992), S. 419-424

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ISSN: 1432-2307

Keywords: Endometrium ; Myometrium ; Lymphocytes ; Gamma interferon

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary T-lymphocytes are present in normal endometrium, where they may have a role in the control of glandular maturation. T-cell activity could be related to the local secretion of cytokines such as gamma interferon, which has an anti-proliferative effect on endometrial epithelial cells in vitro. We have examined gamma interferon immunoreactivity and T-cell distribution in 24 normal pre-menopausal uteri. Endometrial appearances were representative of all stages of the menstrual cycle. Most cells in the lymphoid aggregates in the stratum basalis were stained by T-cell and gamma interferon antisera. T-lymphocytes were also scattered in glandular epithelium and throughout the stroma of basal and functional layers; immunoreactivity for gamma interferon was less consistent in these cells. There was no alteration in the intensity or distribution of gamma interferon staining in different phases of the menstrual cycle. Endometrial granulocytes (K-cells) present mainly in the late secretory endometria were not reactive with the gamma interferon antiserum. In addition to endometrial staining, T-cells were distributed in all areas of the myometrium in most uteri, and many myometrial lymphocytes were gamma interferon positive. These results support a role for gamma interferon in endometrial physiology, possibly as an inhibitor of epithelial proliferation.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01600513

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Conformational preferences of XONO2 systems (X = H, F, Cl, CH3) from ab initio techniques (1991)

Smith, Brian J. ; Marsden, Colin J.

New York, NY [u.a.] : Wiley-Blackwell

Journal of Computational Chemistry 12 (1991), S. 565-574

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ISSN: 0192-8651

Keywords: Computational Chemistry and Molecular Modeling ; Biochemistry

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology , Computer Science

Notes: Ab initio SCF and MP2 methods have been used to calculate the geometries and relative energies of both planar and nonplanar rotamers of several nitrates with a DZP basis set. The planar arrangement of atoms is found to be the lower energy configuration in all cases. The interconversion between rotamers is analyzed by partitioning the contributions to the total SCF energy in a variety of ways.

Additional Material: 4 Ill.