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  • 11
    Electronic Resource
    Electronic Resource
    Observation of quantum supershells in clusters of sodium atoms (1991)
    [s.l.] : Nature Publishing Group
    Nature 353 (1991), S. 733-735 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The semiclassical theory of Balian and Bloch4 was extended and applied to idealized spherical sodium droplets with somewhat diffuse potential walls6. A quantum beat was found in the shell structure, with a pronounced minimum being predicted around size N - 1,000. The semiclassical results were ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/353733a0
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  • 12
    Electronic Resource
    Electronic Resource
    Circadian variation of blood pressure in patients with diabetic nephropathy (1992)
    Springer
    Diabetologia 35 (1992), S. 1074-1079 
    Details
    ISSN: 1432-0428
    Keywords: Type 1 (insulin-dependent) diabetes mellitus ; diabetic nephropathy ; ambulatory blood pressure ; circadian ; variation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The association between diurnal blood pressure variation and diabetic nephropathy was assessed in four groups of Type 1 (insulin-dependent) diabetic patients who underwent 24-h ambulatory blood pressure monitoring using an oscillometrie technique. Patients with nephropathy, who had never been treated for hypertension (group D3,n = 13), were individually matched for age, sex and diabetes duration to a group of microalbuminuric patients (D2,n = 26), to normoalbuminuric patients (D1,n = 26) and to healthy control subjects (C,n = 26). Group D3 was also compared to patients with advanced nephropathy receiving treatment for hypertension, mainly a combination of angiotensin converting enzyme inhibitors, metoprolol and diuretics (D4,n = 11). In group D3 24-h diastolic blood pressure (85 ± 8 mm Hg) was comparable to the results obtained in D4 (85 ± 8 mm Hg) but significantly higher than in D2 (78 ± 7 mm Hg), D1 (73 ± 7 mm Hg) and C (73 ± 7 mm Hg,p 〈 0.05, Tukey's test). The night/day ratio of diastolic blood pressure was higher in D3 (86 ± 5 %) and D2 (85 ± 7%) than in C (80 ± 7 %,p 〈 0.02). This ratio was also elevated in group D4 (94 ± 8%) compared to D3 (p 〈 0.05) corresponding to a marked smoothing of the diurnal blood pressure curve. The 24-h heart rate (beats per min) was significantly elevated in D3 (84 ± 8) and D2 (80 ± 10) compared with C (73 ± 11,p 〈 0.05 Tukey's test), suggesting the presence of parasympathetic neuropathy In conclusion the normal circadian variation of blood pressure was moderately disturbed in a group of microalbuminuric patients and patients with less advanced overt nephropathy. Patients with advanced diabetic nephropathy receiving antihypertensive therapy showed a marked reduction of nocturnal blood pressure fall, which can only be identified by the application of ambulatory blood pressure measurements to verify the 24-h effectiveness of blood pressure control.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02221684
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  • 13
    Electronic Resource
    Electronic Resource
    Trapezius muscle load as a risk indicator for occupational shoulder-neck complaints (1993)
    Springer
    International archives of occupational and environmental health 64 (1993), S. 415-423 
    Details
    ISSN: 1432-1246
    Keywords: Shoulder-neck complaints ; Electromyographic recordings ; Static work loads
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Upper trapezius muscle activity was quantified by electromyogräphic (EMG) recordings using surface electrodes to study occupational muscle load as a risk indicator for the development of shoulder-neck complaints. Thirty-nine female' production workers and thirty-two female office workers showed much larger interindividual differences than the mean difference in muscle activity between the two groups. By comparison with the production workers, the muscle activity patterns of the office workers were characterized by more short pauses and a lower static load. The median load level was similar for the two groups. For the office workers, but not for the production workers, weak correlations were found between symptoms of pain in the shoulder-neck region and some of the EMG parameters (static level and frequency of micropauses 〉 0.6 s. Current techniques for measuring shoulder muscle load by EMG recordings seem inadequate as screening methods to predict future risk of development of muscle pain symptoms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00517947
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  • 14
    Electronic Resource
    Electronic Resource
    Individual and work-related risk factors associated with symptoms of musculoskeletal complaints (1993)
    Springer
    International archives of occupational and environmental health 64 (1993), S. 405-413 
    Details
    ISSN: 1432-1246
    Keywords: Musculoskeletal complaints ; Risk factors ; Repetitive work tasks ; Static loads
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Individual and work-related risk factors in the development of occupational musculoskeletal complaints were investigated in a cross-sectional study of 52 female production workers and 34 female office workers. The work tasks of the production workers were considered to generate shoulder muscle loads of low amplitude and high repetitiveness, and the work tasks of the office workers, muscle loads of low amplitude and low repetitiveness. The symptom scores were similar in the two groups, with the highest score for both groups in the shoulder-neck region. Previous pain symptoms were an important risk factor for musculoskeletal pain in all body regions, whereas psychosocial problems at work were a risk factor for complaints in the shoulder-neck region. For the office workers, 27% of the variance in shoulder-neck symptoms was explained by the variance in the parameters “previous pain symptoms” and “psychosocial problems” in a multilinear regression model. In three groups of workers with different physical loads on the shoulder muscles the symptom scores for workers without previous pain symptoms and psychosocial problems were related to the physical load. For workers with previous pain symptoms and psychosocial problems, the symptom scores were high and similar for all three groups.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00517946
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  • 15
    Electronic Resource
    Electronic Resource
    Tuberkulose und Schwangerschaft (1935)
    Springer
    Lung 86 (1935), S. 624-662 
    Details
    ISSN: 1432-1750
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02141623
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  • 16
    Electronic Resource
    Electronic Resource
    Management of Peutz-Jeghers syndrome (1994)
    Springer
    International journal of colorectal disease 9 (1994), S. 177-179 
    Details
    ISSN: 1432-1262
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Les patients danois porteurs d'un syndrome de Peutz-Jeghers sont enregistrés dans le registre danois des polyposes. Nous avons débuté un nouveau programme de follow-up en nous basant sur les données récentes de la littérature et sur nos propres cas. Le suivi a été ajusté sur la vitesse de croissance des polypes alors que chez les patients asymptomatiques et qui présentaient un taux de croissance lent, les contrôles ont pu être espacés. Le programme comporte des endoscopies hautes et basses du tractus gastro-intestinal, un transit baryté suivi et, dans certains cas, chez des porteurs de polypes étendus ou asymptomatiques, une laparotomie a été réalisée avec une entéroscopie pertopératoire totale complétée par des polypectomies. Un examen de la cavité pelvienne, un frottis cervical, une palpation du sein et des testicules ont été réalisés chez toux les patients âgés de plus de 30 ans.
    Notes: Abstract Danish patients with Peutz-Jeghers syndrome are registered in the Danish Polyposis Register. We have initiated a new follow-up programme based on recent literature including our own cases. This has been adjusted to the regrowth rate of the polyps whereby patients with no symptoms and low regrowth rate are followed with few examinations. The programme includes upper and lower gastrointestinal endoscopy, small bowel enema and in cases with large or symptomatic polyps, laparotomy with intraoperative total enteroscopy with polypectomy as required. Pelvic examination, cervical smear, breast and testicular examination are carried out after the age of 30 years.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00292244
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  • 17
    Electronic Resource
    Electronic Resource
    Über einige ungewöhnliche Allergieformen und Allergenanlässe (1941)
    Springer
    Medical microbiology and immunology 123 (1941), S. 486-493 
    Details
    ISSN: 1432-1831
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Es wurde versucht, durch einige genau analysierte Beispiele hinzuweisen: 1. auf die krankmachende Bedeutung einiger Arzneimittelantigene, die sonst im allgemeinen gut vertragen werden und darum als „unschädlich” gelten, 2. auf die Bedeutung der „Herdreaktion” bei den allergischen Erkrankungen, d. h. auf die Tatsache, daß bei oberflächlichem Antigenkontakt neben der Kontaktstelle selbst („örtliche Reaktion”) oft auch das fernabgelegene, individuellprädisponierte allergische Reaktionsorgan spezifisch anspricht („Herdreaktion”).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02177946
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  • 18
    Electronic Resource
    Electronic Resource
    Acute renal effects of angiotensin converting enzyme inhibition in microalbuminuric type 1 diabetic patients (1993)
    Springer
    Acta diabetologica 30 (1993), S. 149-153 
    Details
    ISSN: 1432-5233
    Keywords: Angiotensin converting enzyme inhibition ; Microalbuminuria ; Renal haemodynamics ; Type 1 diabetes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The renal effects of intravenous injection of 40 mg enalapril were investigated in 16 normotensive microalbuminuric type 1 (insulin-dependent) diabetic patients. After enalapril the following changes were observed: fractional albumin clearance (Θ Alb) decreased from 9.9 (3.0–23.8) to 8.2 (2.0–18.3)×10−6 (2P〈0.01); filtration fraction (FF) decreased from 0.260 (0.225–0.312) to 0.253 (0.190–0.297) (2P〈0.01); renal plasma flow (RPF) increased from 565 (411–690) to 623 (449–785) (2P〈0.01); and glomerular filtration rate (GFR) remained stable at 149 (128–181) versus 150 (124–185) ml · min−1 (NS). These values were unchanged after placebo (n=8), except for RFP which decreased from 606 (401–701) to 559 (381–677) ml · min−1 (2P〈0.05) and GFR which was reduced from 148 (111–173) to 138 (111–167) (2P〈0.05). A reduction in mean blood pressure from 94 (87–103) to 89 (79–101) mmHg (2P〈0.05) was found in the enalapril group and a minor reduction in the placebo group from 97 (83–106) to 96 (81–104) mmHg (2P〈0.05) was also noted. The relative changes in systolic blood pressure in the enalapril group correlated with changes in Θ Alb (Spearman'sr=0.66, 2P〈0.02) and FF (r=0.53, 2P〈0.05). Acute inhibition of angiotensin converting enzyme does not reduce the pathological hyperfiltration in these patients and a reduction in Θ Alb and FF can not be dissociated from the reduction in blood pressure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00572859
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  • 19
    Electronic Resource
    Electronic Resource
    Reduced glomerular filtration rate and cardiovascular damage in diabetes: a key role for abnormal albuminuria (1992)
    Springer
    Acta diabetologica 29 (1992), S. 201-213 
    Details
    ISSN: 1432-5233
    Keywords: Abnormal albuminuria ; ACE-inhibition ; Hypertension ; Microalbuminuria ; Diabetic nephropathy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract There is general agreement that a fall rate in glomerular filtration rate (GFR) is the principal endpoint in diabetics with renal disease, and that abnormal albuminuria (including microalbuminuria) is an important intermediate end-point. The relative roles of blood pressure (BP) elevation and abnormal albuminuria in the prediction and genesis of renal disease are a matter of debate, and are further analysed in this paper. New studies show that neither genetic predisposition to hypertension (parental BP) nor parental abnormal albuminuria can be used to predict renal disease in patients with type 1 (insulin-dependent) diabetes. However, parental predisposition to proteinuria seems to be important to certain types of patients with type 2 (non-insulin-dependent) diabetes. Cross-sectional as well as follow-up studies document that GFR is generally well preserved in microalbuminuria (in both type 1 and type 2 patients), while the transition to clinical proteinuria is associated with a decline in GFR. Thus, prevention of overt proteinuria is important in clinical trials in microalbuminuric patients. In type 1 diabetes clear ultrastructural changes have been documented with microalbuminuria and a good correlation between abnormal albuminuria and structural damage is seen. Structural damage in normo- and microalbuminuric patients correlates poorly with BP. New studies in type 1 diabetes document that microalbuminuria (but not elevated BP) predicts not only clinical diabetic nephropathy but also end-stage renal failure and mortality. In type 2 diabetes microalbuminuria is the strongest predictor of mortality, whereas BP elevation is not a predictor. Several studies now document that antihypertensive treatment, especially with inhibitors of angiotensin converting enzyme, is able to reverse or reduce abnormal albuminuria, even in non-hypertensive type 1 patients, and possibly preserve GFR. Therefore, microalbuminuria may be the main indicator for starting antihypertensive treatment in these patients. With respect to organ damage in the retina, abnormal albuminuria is an important indicator of the risk of severe diabetic retinopathy. BP elevation seems not to be an initiating factor, but rather aggravates established retinopathy. Left ventricular hypertrophy has a stronger correlation with BP elevation than normoalbuminuria, suggesting that left ventricular hypertrophy is at least partially a phenomenon secondary to elevated BP in diabetic patients with abnormal albuminuria. Generally, abnormal albuminuria is a strong indicator of cardiovascular renal damage in diabetic patients and in most organs is a stronger factor than elevated BP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00573489
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  • 20
    Electronic Resource
    Electronic Resource
    Stress urinary incontinence in postmenopausal women treated with oral estrogen (estriol) and an alpha-adrenoceptor-stimulating agent (phenylpropanolamine): A randomized double-blind placebo-controlled study (1990)
    Springer
    International urogynecology journal 1 (1990), S. 74-79 
    Details
    ISSN: 1433-3023
    Keywords: Stress incontinence ; Estriol ; Phenylpropanolamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Twenty-eight postmenopausal women with objectively verified stress incontinence completed a randomized double-blind placebo-controlled study. After an initial 4 weeks of placebo treatment the patients received either oral estriol (E3) (4mg daily) or oral phenylpropanolamine (PPA) (50 mg b.i.d.) alone for 4 weeks, followed by another 4 weeks of treatment with the two active drugs in combination. Subjectively, 14 of 15 patients preferred PPA to placebo (P〈0.001), 9 of 12 patients preferred E3 to placebo (P=0.011), and 10 of 14 patients preferred E3 + PPA to E3 (P=0.006). Two patients became continent on PPA, 2 on E3, and 12 of 28 patients on combined treatment. PPA gave a significant decrease in urine loss when compared with placebo (P=0.023), and the combined treatment of PPA + E3 also gave a reduction in urine loss when compared with placebo (P=0.022). It is concluded that estriol 4mg daily and PPA 50 mg b.i.d. are effective in the treatment of stress urinary incontinence in postmenopausal women. The enhanced effect of combined treatment is moderate and of questionable importance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00600025
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