ISSN:
1432-1238
Keywords:
High frequency jet ventilation
;
Panlobular emphysema
;
Lung volume
;
Auto-PEEP
;
Papain
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The effects of high frequency jet ventilation (HFJV, f=2 Hz and 8 Hz, I:E=0.43, FiO2=0.4) were studied and compared with intermittent positive pressure ventilation (IPPV, f=10–14 breaths/min, VT=15 ml/kg, I:E=0.5, FiO2=0.4) in 8 dogs before and after induction of panlobular emphysema (PLE). PLE increased alveolar-arterial PO2 difference (PA-aO2) during all modes of ventilation, whereas PaCO2 did not change significantly. In both periods of the study, HFJV8Hz was less effective in terms of CO2-elimination and oxygenation. In the control-period, functional residual capacity (FRC) was 937±212 ml. The increase during HFJV (HFJV2Hz:1156±508 ml, HFJV8Hz:1153±433 ml) did not reach significance (P=0.09). Closing volume (CV) increased from 1.5±4.3% of vital capacity (%VC) (IPPV) to 6.3±7.1%VC (HFJV2Hz) and 10.8±9.8% VC (HFJV8Hz), respectively. In the PLE-period, FRC and CV increased significantly to 1107±207 ml and 14.1±7.0% VC respectively during IPPV (P〈0.05). Application of HFJV neither increased FRC (HFJV2Hz: 1153±433 ml, HFJV8Hz: 1005±344 nor CV 14.8±6.0% VC and 13.9±8.1% VC, respectively). It is concluded that HFJV induces no alveolar overdistension in dogs with emphysematous lungs.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01720673
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