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  • 1990-1994  (3)
  • 1840-1849
  • Polymer and Materials Science  (2)
  • Ca agonists  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Pflügers Archiv 424 (1993), S. 343-353 
    ISSN: 1432-2013
    Keywords: Ca channel ; (−) BAY K 8644 ; Ca agonists ; Cardiac cells ; Ca current ; Mode of action ; Dihydropyridine receptor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The primary drug action of (−) BAY K 8644 on whole-cell Ca current in atrial myocytes was measured under conditions where secondary Ca-mediated changes of Ca channel activity were minimized. The most direct action of (−) BAY K 8644 is the change of gating kinetics which results in a strictly voltage-dependent increase of the peak current in the voltage range between −40 and 0 mV. Peak currents were increased dose dependently in the concentration range from 1 to 30 nM. Analysis of peak current/voltage relations revealed a linear shift of the current activation by approximately 23 mV to more negative membrane potentials, without any change in its voltage dependence and in the current reversal potential or the maximum whole-cell conductance. Measurement of Ca current activation and deactivation time constants suggests that (−) BAY K 8644 prolongs the single-channel open time without affecting the closed time. From the shift of the open time function to more negative voltages by about 50 mV the energy transferred to the gating process is calculated to be 5.4 kJ/mol (1.3 kcal/mol). The drug-induced slow component of tail current has been used to estimate the true dose/response relation for (−) BAY K 8644. A K D value of 4.3 nM and a Hill coefficient of 1.25 were determined. Flash-induced competition experiments with the Ca antagonist nifedipine allowed the measurement of binding kinetics of (−) BAY K 8644. The association rate constant is estimated to about 5×106 mol−1 · s−1 and dissociation time constant is approximately 50–70 s; both are in close agreement with receptor binding studies. Results are discussed in relation to models for drug action of dihydropyridine-type compounds and to implications for the structure of the Ca channel protein.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Materialwissenschaft und Werkstofftechnik 22 (1991), S. 427-433 
    ISSN: 0933-5137
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Description / Table of Contents: It is the aim of the investigations on a PBTP-glass-spherecomposite to get experimental well-founded informations about the state of stress in the polymer matrix of the composite. The used method was the x-ray-lattice strain-stress measurement.The result of the measurements is the proof of a 3-axial state of tension stress in the polymer matrix in the unloaded state as well as under an uniaxial tension load. The reason are differences in the elastic properties of the two components in this heterogenous built up composite.
    Notes: Die Untersuchungen an einem PBTP-Glaskugel-Verbundwerkstoff haben das Ziel, experimentell begründete Aussagen über den Spannungszustand in der Polymermatrix des Verbundwerkstoffes zu gewinnen. Als Meßverfahren wurde die röntgenographische Spannungsmessung verwendet.Im Ergebnis der Messungen konnte in der Polymermatrix des Verbundwerkstoffes sowohl im unbelasteten Zustand als auch bei einachsiger äußerer Zugbeanspruchung ein mehrachsiger Zugspannungszustand nachgewiesen werden. Er ist durch die Unterschiede in den elastischen Eigenschaften der beiden Komponenten des heterogenen aufgebauten Verbundwerkstoffes bedingt.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Chemie Ingenieur Technik - CIT 66 (1994), S. 1213-1213 
    ISSN: 0009-286X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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