ISSN:
1434-4726
Keywords:
Otitis media with effusion
;
Haemophilus influenzae infection
;
Bacterial adherence
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Since mucosal colonization may be an important determinant in the pathogenesis of otitis media with effusion (OME), we studied the adherence of Haemophilus influenzae (HI) to human nasal, nasopharyngeal, and buccal mucosal cells obtained from patients with OME. Non-typeable HI adhered in significantly greater numbers than type b HI. HI bacteria adhered to both nasal and nasopharyngeal mucosal cells in significantly greater numbers than to buccal ones. Non-typeable HI adhered to the epithelial cells from children with chronic sinusitis in more significant numbers than did those from children without chronic sinusitis. These results indicate that non-typeable HI adhere more readily to epithelial cells and that the nasal and nasopharyngeal mucosa may be an important route for HI infection in OME.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00183182
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