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  • 1990-1994  (3)
  • metastasis  (2)
  • Analytical Chemistry and Spectroscopy  (1)
  • (R)-(+)-1,1′-bi-2,2′-naphthol
  • Blurry image
  • Camera model
  • Cis-Parinaric acid = fluorescent probe for lipid peroxidation
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Material
Years
Year
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Fatty acid modulation of tumor cell-platelet-vessel wall interaction (1992)
    Springer
    Cancer and metastasis reviews 11 (1992), S. 389-409 
    Details
    ISSN: 1573-7233
    Keywords: 12(S)-HETE ; 13(S)-HODE ; TXA2 ; PGI2 ; platelet ; vessel wall ; metastasis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Prostaglandins and other eicosanoids have been studied extensively in their physical, biochemical, biophysical and pharmacological aspects. However, studies on their role in tumor progression, especially metastases are relatively recent. Following a brief overview of the history of discovery and metabolism of eicosanoids and other fatty acids, we discuss the functions of these fatty acids (with emphasis on prostacyclin, thromboxane A2, 12-hydroxyeicosatetraenoic acid and 13-hydroxyoctadecadienoic acid) in cell transformation, tumor promotion and particularly in tumor cell metastasis. The relation between these monohydroxy fatty acids and tumor cell metastasis is discussed from three different perspectives, i.e., their effects on tumor cells, on platelets and on endothelial cells. The mechanism of these effects are then addressed at cell adhesion molecule, motility, protease, cell cytoskeleton, protein kinase and eicosanoid receptor levels. Finally, regulation of three key enzymes which generate eicosanoids (phospholipase, prostaglandin endoperoxide synthase and lipoxygenase) is explored.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01307189
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Membrane proteases as potential diagnostic and therapeutic targets for breast malignancy (1994)
    Springer
    Breast cancer research and treatment 31 (1994), S. 217-226 
    Details
    ISSN: 1573-7217
    Keywords: glycoprotein ; invasion ; malignancy marker ; membrane ; metastasis ; protease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Metastasizing cancer cells can invade the extracellular matrix using plasma membrane protrusions, termed invadopodia, that contact and dissolve the matrix. Various membrane associated proteases localized on the invadopodial membranes are responsible for the extracellular matrix degradation. Work from our laboratory shows that secreted proteases including Gelatinase A, and high molecular weight integral membrane proteases are associated with cell surface invadopodia. Three cell types, including chicken embryonic cells transformed by Rous sarcoma virus, human malignant melanoma cell line LOX, and human breast carcinoma cell line MDA-MB-231, retain the invasive phenotypein vitro, express invadopodia, degrade and enter into a fibronectin-rich collagenous matrix. We suggest that invadopodium-associated proteases are ideal targets for the diagnosis and treatment of cancer as their presence in association with primary tumors may signal increased metastatic potential. An approach toward the development of new prognostic markers for breast malignancy involved production of monoclonal antibodies directed against membrane proteases in a mixture of glycoproteins. Double immunofluorescent technique using a known invadopodium marker is designed to select specific monoclonal antibodies colocalizing at the invasion front, on invadopodia of cancer cells. Membrane protease accessibility at the cell surface can therefore be exploited for therapeutic advances by the development of specific antibodies and inhibitors that block their activities, and by the use of monoclonal antibodies to target cytotoxic molecules to micrometastases. Also, this same accessibility may potentially be used to detect surface proteases on micrometastases or to detect components shed by micrometastases in serum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00666155
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Analytical merit of electrospray ion mobility spectrometry as a chromatographic detector (1994)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Microcolumn Separations 6 (1994), S. 515-524 
    Details
    ISSN: 1040-7685
    Keywords: electrospray ionization ; ion mobility detection ; ion mobility spectrometry ; liquid chromatography detector ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Electrospray ionization ion mobility spectrometry (ESI-IMS), a technique which has only recently become analytically useful, has been evaluated for use as a detector for microbore liquid chromatography and capillary electrophoresis. Figures of merit for ESI-IMS were determined. Detection limits as low as 1 × 10-15 mol s-1 were measured, with a linear response range of 3 to 4 orders of magnitude and with reproducibility within 3% (relative standard deviation of peak area). Gradient elution with water/methanol mobile phase did not perturb chromatographic baseline, compound response, or product ion mobility. Both positive and negative ion mobility spectra for more than 30 compounds demonstrated the sensitivity of ESI-IMS response to a wide range of analytes. Finally, the concept of using ESI-IMS as an ionization source for gasphase samples was presented, potentially unifying detector application for both gas and liquid chromatography.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mcs.1220060511
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    Paper (German National Licenses)
    Fulltext
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