ISSN:
1432-1041
Keywords:
Bemetizide
;
Salt excretion pattern
;
Na+
;
K+
;
Cl−
;
Mg2+
;
Ca+
;
chronic renal failure
;
renal haemodynamics
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Abstract The effect of the thiazide diuretic, bemetizide, on the excretion of Na+, K+, Cl−, Ca2+, and Mg2+ in relation to the glomerular filtration rate (GFR) was studied in 17 subjects whose creatinine clearances ranged from 133 to 5 ml·min−1. After a 2-day fluid and salt balanced control period, 25 mg bemetizide given orally induced natriuresis and kaliuresis which lasted for 24 h and were proportional to the GFR of the patients. The ratio of bemetizide-induced K+/Na+ excretion was always 0.17 irrespective of individual GFR. In renal failure, bemetizide increased the fractional Na+ excretion from 3% to about 10%. Kaliuresis was associated with magnesiuria, whereas bemetizide-induced calciuresis was insignificant. The thiazide reversibly lowered GFR in all subjects.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00195908
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