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  • 1990-1994  (4)
  • Amyotrophic lateral sclerosis  (2)
  • Chemistry  (2)
  • Adenylate cyclase
  • Astrocyte
  • cDNA cloning
  • 1
    Electronic Resource
    Electronic Resource
    Clarke's column in sporadic amyotrophic lateral sclerosis (1992)
    Springer
    Acta neuropathologica 84 (1992), S. 465-470 
    Details
    ISSN: 1432-0533
    Keywords: Amyotrophic lateral sclerosis ; Clarke's column ; Bunina body ; Spheroid ; neuronal loss
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Histological, ultrastructural and morphometrical observations on Clarke's column were carried out in 18 patients with sporadic amyotrophic lateral sclerosis (ALS) and 15 age-matched control subjects. Of the 18 ALS patients 6 had been on a respirator before death. Bunina bodies were found in the neuronal cytoplasm in 7 of the 12 non-respirator-supported ALS patients and in 3 of the 6 respirator-supported patients. The number of spheroids was significantly higher in the non-respirator-supported patients (P〈0.01) than in the control subjects; however, the number in the respirator-supported patients was about equal to that in the controls. The number of neurons in Clarke's column in the non-respirator-supported ALS patients was not reduced, but in the respirator-supported patients they tended to disappear with time after respiratory support. These findings suggest that Clarke's column neurons are also involved primarily in the disease process in sporadic ALS. However, they may begin to disappear only after the patients require respiratory support.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00304464
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The intermediolateral nucleus in sporadic amyotrophic lateral sclerosis (1993)
    Springer
    Acta neuropathologica 86 (1993), S. 190-192 
    Details
    ISSN: 1432-0533
    Keywords: Amyotrophic lateral sclerosis ; Intermediolateral nucleus ; Quantitative examination ; Bunina body ; Neuronal loss
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Histological and morphometrical observations of the intermediolateral nucleus (IML) at the levels of the upper and lower thoracic segments (T2 and T9) were carried out in 18 patients with sporadic amyotrophic lateral sclerosis (ALS) and 15 age-matched control subjects. Of the 18 ALS patients 6 had been on a respirator before death. No Bunina bodies were found in the IML neurons in either the ALS patients or the control subjects. Only a small number of spheroids were encountered rarely in the IML in both the patients and controls. The number of neurons in the IML in the non-respirator-supported ALS patients were reduced at T2, but well preserved at T9 compared with the control subjects. In the respirator-supported ALS patients, there was a marked reduction of IML neurons at both T2 and T9. Considering the absence of direct synaptic contacts with anterior horn cells, these neurons, without the formation of Bunina bodies, appeared to be involved primarily in the disease process in sporadic ALS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00334889
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Ester-type photosensitive polyimide precursor with low thermal expansion coefficient (1992)
    Stamford, Conn. [u.a.] : Wiley-Blackwell
    Polymer Engineering and Science 32 (1992), S. 1618-1622 
    Details
    ISSN: 0032-3888
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: For an ester-type photosensitive polyimide precursor of low thermal expansion coefficient, the oxygen concentration in the curing process and the molecular weight of the polyimide precursor were found to control the properties of the polyimide. The effects of these factors on the thermal expansion coefficient, tensile strength, and modulus of polyimide film were investigated. Based on these results, a photosensitive polyimide with low thermal expansion coefficient, called the PIMEL TL-series, was developed. Crack and delamination free multilayers were successfully achieved using this newly developed product.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pen.760322114
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Phase separation in mixtures of poly(ethylene glycol monomethylether) and poly(propylene glycol) oligomers (1991)
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part B: Polymer Physics 29 (1991), S. 1419-1425 
    Details
    ISSN: 0887-6266
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Time-resolved light scattering was employed to investigate kinetics of phase separation in mixtures of poly (ethylene glycol monomethylether) (PEGE)/poly (propylene glycol) (PPG) oligomers. Phase diagrams for PEGE/PPG of varying molecular weights were established by means of cold point measurements. The oligomer mixtures reveal an upper critical solution temperature (UCST). Several temperature quench experiments were carried out with a 60/40 PEGE/PPG blend by rapidly quenching from a single phase (69°C) to two-phase temperatures (66-61°C) at 1°C intervals. As is typical for oligomer mixtures, the early stage of spinodal decomposition (SD) was not detected. The kinetics of phase decomposition was found to be dominated by the late stage of SD. Time-evolution of scattering intensity was analyzed in accordance with nonlinear and dynamical scaling theories. The time dependence of the peak intensity Im and the corresponding peak wavenumber qm was found to follow the power-law {Im(t)˜ tα, qm(t)˜ t-β} with the values of α = 3 ± 0.3 and β = 1 ± 0.2, which are very close to the values predicted by Siggia. This process has been attributed to a coarsening mechanism driven by surface tension. In the temporal scaling analysis, the structure function reveals university with time, suggesting self-similarity. Phase separation dynamics in 60/40 PEGE/PPG resembles the behavior predicted for off-critical mixtures.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/polb.1991.090291110
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    Paper (German National Licenses)
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