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  • 1990-1994  (3)
  • Lymphocytes  (2)
  • Affective disease  (1)
  • Biometeorological predictions  (1)
  • Amyotrophic lateral sclerosis
  • Classification of gliomas
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Year
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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    International journal of biometeorology 36 (1992), S. 45-50 
    ISSN: 1432-1254
    Keywords: Biometeorological predictions ; Leaf wetness duration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geography , Physics
    Notes: Abstract A classification of daily weather types is used to obtain typical deviations of daily maximum and minimum air temperatures, global radiation, amount of precipitation, mean daily relative humidity at 1400 hours local time, meteorological water balance, grass minimum temperature at a height above the turf of 5 cm and duration of daily leaf wetness for SW Germany (Stuttgart area) from the corresponding monthly means. The period of reference was the growing season from May to September for the 5 years 1980–1984. Medium-range weather forecast maps for the ground surface and the 850 hPa level are issued daily for 5 days in advance by the medium-range weather forecasting centre at Reading (ECMWF). The forecasts are valid for Western Europe and have been used to transform the forecasted flow pattern and air pressure distribution, both on the ground and at the 850 hPa level into Central European weather types, following the classification mentioned above. The seasonal variability (from May to September) has been found to be small enough to be able to present the results as a single table for the whole vegetation period. The deviation of the forecasted values from the observed values are compared, using as test period the 1988 and 1989 seasons. The forecasts were: (i) persistency forecasts (the same deviations are forecasted for the next 5-days period); (ii) supposed weather types during the next 5 days, derived from ECMWF with expected deviations of the meteorological elements from the seasonal mean; and (iii) “real” weather types, classified officially from the German Weather Service using mean deviations of the meterological elements from the seasonal means. The means obtained on the 5-day deviations are discussed. The values were, for exemple, 2 K for minimum temperature, about 3 K for maximum temperature, 20% of the values for global radiation, 1.5 mm for the amount of daily precipitation and 16% for the daily duration of leaf wetness. The mean relative deviations differed between the various meterological elements, being smaller for elements mainly related on the macro-/mesoscale than for elements such as minimum temperatures that are mainly related to the microclimate.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Psychopharmacology 104 (1991), S. 45-50 
    ISSN: 1432-2072
    Keywords: Lithium ; Carbamazepine ; Guanylate cyclase ; Lymphocytes ; Mechanism of action
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Although a large variety of biochemical effects have been reported for lithium (Li) and carbamazepine (Cbm), the final molecular mechanism underlying their therapeutic efficacy for recurrent affective disorders is still unknown. The data presented here clearly indicate that therapeutic concentrations of both drugs inhibit sodium nitroprusside-induced accumulation of cGMP in human lymphocytes to about the same extent. The effect is not seen for other antidepressants, and shows pronounced interindividual variations in healthy volunteers. A similar effect of lithium and carbamazepine can also be demonstrated for the cGMP accumulation of central neurons using the model of dissociated cells of the mouse brain. The results are discussed in view of a common mechanism of action of both drugs. Furthermore, it is speculated that the individual sensitivity of the cGMP generating system of human lymphocytes to both drugs might be used to predict therapeutic response or nonresponse of the individual patient.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    European archives of psychiatry and clinical neuroscience 243 (1994), S. 235-239 
    ISSN: 1433-8491
    Keywords: Intracellular calcium ; Affective disease ; Platelets ; Lymphocytes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Many studies have demonstrated pharmacologic similarities between platelet and brain 5-HT2 binding sites. Therefore it may be possible to use platelets as a model for the central serotonergic neuron. Accordingly, a previcus report (Kusumi et al. 1991b) about elevated [Ca2+]i after serotonin stimulation in platelets of depressed patients was interpreted as further evidence for enhanced serotonergic sensitivity in depression. However, a very recent study showed an enhanced thrombin-induced platelet Ca2+ response, rather suggesting abnormalities of intracellular Ca2+ regulation in affective disorders. In the present study we have determined 5-HT2-and thrombin-induced Ca2+ responses in platelets and additionally phytohemagglutin (PHA)-induced Ca2+ increase in lymphocytes of medicated depressed patients (8 mono- and 2 bipolar, HRSD〉17) and of ten sex- and age-matched controls. The results showed no significant difference in basal calcium levels between the two groups and no significant difference in the Ca2+ response to thrombin although the response was higher in the patients. The Ca2+ increase after serotonin stimulation in depressed patients was significantly (P〈0.05) higher than in healthy controls. By contrast, the Ca2+ response to PHA in lymphocytes was significantly decreased in the patients. Our data confirm elevated Ca2+ responses after 5-HT2 receptor activation even in medicated depressed patients. However, Ca2+ responses in lymphocytes were decreased. Together with the observations of an enhanced Ca2+ response in platelets after thrombin stimulation, we speculate that the findings rather suggest alterations of [Ca2]i regulation in depression than specific changes of serotonergic sensitivity.
    Type of Medium: Electronic Resource
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