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  • 1990-1994  (8)
  • Polymer and Materials Science  (6)
  • Lymphocytes  (2)
  • Affective disease  (1)
  • Amyotrophic lateral sclerosis
  • Classification of gliomas
Material
Years
Year
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Psychopharmacology 104 (1991), S. 45-50 
    ISSN: 1432-2072
    Keywords: Lithium ; Carbamazepine ; Guanylate cyclase ; Lymphocytes ; Mechanism of action
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Although a large variety of biochemical effects have been reported for lithium (Li) and carbamazepine (Cbm), the final molecular mechanism underlying their therapeutic efficacy for recurrent affective disorders is still unknown. The data presented here clearly indicate that therapeutic concentrations of both drugs inhibit sodium nitroprusside-induced accumulation of cGMP in human lymphocytes to about the same extent. The effect is not seen for other antidepressants, and shows pronounced interindividual variations in healthy volunteers. A similar effect of lithium and carbamazepine can also be demonstrated for the cGMP accumulation of central neurons using the model of dissociated cells of the mouse brain. The results are discussed in view of a common mechanism of action of both drugs. Furthermore, it is speculated that the individual sensitivity of the cGMP generating system of human lymphocytes to both drugs might be used to predict therapeutic response or nonresponse of the individual patient.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European archives of psychiatry and clinical neuroscience 243 (1994), S. 235-239 
    ISSN: 1433-8491
    Keywords: Intracellular calcium ; Affective disease ; Platelets ; Lymphocytes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Many studies have demonstrated pharmacologic similarities between platelet and brain 5-HT2 binding sites. Therefore it may be possible to use platelets as a model for the central serotonergic neuron. Accordingly, a previcus report (Kusumi et al. 1991b) about elevated [Ca2+]i after serotonin stimulation in platelets of depressed patients was interpreted as further evidence for enhanced serotonergic sensitivity in depression. However, a very recent study showed an enhanced thrombin-induced platelet Ca2+ response, rather suggesting abnormalities of intracellular Ca2+ regulation in affective disorders. In the present study we have determined 5-HT2-and thrombin-induced Ca2+ responses in platelets and additionally phytohemagglutin (PHA)-induced Ca2+ increase in lymphocytes of medicated depressed patients (8 mono- and 2 bipolar, HRSD〉17) and of ten sex- and age-matched controls. The results showed no significant difference in basal calcium levels between the two groups and no significant difference in the Ca2+ response to thrombin although the response was higher in the patients. The Ca2+ increase after serotonin stimulation in depressed patients was significantly (P〈0.05) higher than in healthy controls. By contrast, the Ca2+ response to PHA in lymphocytes was significantly decreased in the patients. Our data confirm elevated Ca2+ responses after 5-HT2 receptor activation even in medicated depressed patients. However, Ca2+ responses in lymphocytes were decreased. Together with the observations of an enhanced Ca2+ response in platelets after thrombin stimulation, we speculate that the findings rather suggest alterations of [Ca2]i regulation in depression than specific changes of serotonergic sensitivity.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Materialwissenschaft und Werkstofftechnik 25 (1994), S. 329-340 
    ISSN: 0933-5137
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Description / Table of Contents: Effect of Process Parameters in Extrusion on Fatigue BehaviourFatigue test specimens were produced by forward extrusion and subsequent heading from conventional steels, P/M steels and AlMg4.5Mn. The strain, die-opening angle, temperature and in some cases the lubricant were varied. For purpose of comparation in some cases also specimens were prepared by machining. S/N curves or cyclic deformation curves were determined mainly by stress-controlled tests.For all materials the time strength was increased by cold forming whereby the effect of strain was stronger than that of the die-opening angle. The time strength of steel is less increased by warm (semihot) forming than by cold forming. The fatigue strength, however, is not necessarily increased by cold or warm forming. After cold forming the P/M steels contrary to conventional steels revealed mainly quasielastic deformation until fracture. After warm forming, however, P/M steels, due to the decrease of porosity, behaved almost like conventional steels. For AlMg4.5Mn specimens prepared by forming - probably due to worse surface quality - revealed a lower fatigue strength than those prepared by machining. Here also a feasible effect of the choice of the lubricant was stated.
    Notes: Aus schemelzmetallurgischen und Sinterstählen sowie AlMg4,5Mn wurden durch Fließpressen und Anstauchen von Köpfen bauteilähnliche Schwingproben hergestellt. Dabei wurden Umformgrad, Schulteröffnungswinkel, Temperatur und z.T. der Schmierstoff variiert. Zu Vergleichszwecken wurden in Einzelfällen Schwingproben spannend hergestellt. Wöhlerkurven oder Wechselverformungskurven wurden zumeist in spannungskontrollierten Versuchen ermittelt. Für alle Werkstoffe wurde eine Erhöhung der Zeitfestigkeit durch eine Kaltumformung beobachtet. Der Einfluß des Schulteröffnungswinkels war schwächer als der des Umformgrades. Eine Halbwarmumformung von Stahl steigert die Zeitfestigkeit weniger als eine Kaltumformung. Die Dauerfestigkeit wird durch Kalt- oder Halbwarmumformung nicht notwendig gesteigert. Die Sinterstähle zeigten kaltfließgepreßt anders als konventionelle Stähle vornehmlich quasielastische Verformung bis zum Bruch. Halbwarmumgeformt verhalten sich Sinterstähle jedoch aufgrund der verringerten Porosität nahezu wie konventionelle. Für AlMg4,5Mn zeigten umgeformte Schwingproben im Vergleich zu spanend gefertigten - vermutlich aufgrund der schlechteren Oberfläche - eine niedrigere Dauerfestigkeit; hier wurde auch ein deutlicher Einfluß des Schmierstoffes beobachtet.
    Additional Material: 16 Ill.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Materialwissenschaft und Werkstofftechnik 25 (1994), S. 341-348 
    ISSN: 0933-5137
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Description / Table of Contents: On the quantitative valuation of thermally activated material reactionsThis paper gives an insight into the fundamentals and application of the quantitative valuation of thermally activated material reactions, especially of static softening processes. Possibilities of calculating based on diffusion and chemical kinetics are reported not only for isothermal, but also generally for thermally nonstationary conditions. The special cases of constant heating or cooling rates and of constant temperatures which nearly exclusively have been described in the literature follow automatically from these more universal equations given here. For a more precise description of softening processes it is proposed that the ARRHENIUS formula is modified and generalized by introducing a temperature threshold value, i.e., a minimum or reference temperature. This allows the material softening process that independently of time always can be observed only above a minimum temperature to be represented in this way also by the physical-mathematical model. Integrals are calculated and explizit solutions are given for characteristic temperature-time dependences. Finally, the fundamental method of determining the model parameters is described.
    Notes: Der Beitrag gibt einen Einblick in Grundlagen und Anwendung der quantitativen Bewertung thermisch aktivierter Werkstoffreaktionen, insbesondere bei statisch ablaufenden Entfestigungsvorgängen. Berechnungsmöglichkeiten werden auf der Grundlage von Diffusion und chemischer Kinetik nicht nur für isotherme, sondern allgemein für thermisch beliebig instationäre Bedingungen angegeben. Die im Fachschrifttum fast ausschließlich betrachteten Spezialfälle konstanter Erwärmungs- oder Abkühlraten und konstanter Temperaturen ergeben sich aus den hier angegebenen allgemeingültigeren Gleichungen zwanglos. Zur präziseren Beschreibung von Entfestigungsvorgängen wird vorgeschlagen, den Arrhenius-Ansatz dahingehend zu modifizieren bzw. zu verallgemeinern, daß ein Temperaturschwellenwert - eine Mindestbzw. Bezugstemperatur - in geeigneter Weise eingeführt wird. Dadurch wird erreicht, daß eine Werkstoffentfestigung, die - praktisch unabhängig von der Zeitdauer - immer erst oberhalb gewisser Mindesttemperaturen beobachtbar ist, in dieser Weise auch durch das physikalisch-mathematische Modell erfaßt und widergespiegelt wird. Für charakteristische Temperatur-Zeit-Abhängigkeiten werden die auftretenden Integrale berechnet und explizite Lösungen angegeben. Abschließend wird der prinzipielle Weg zur Bestimmung der Modellparameter skizziert.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Chemie Ingenieur Technik - CIT 64 (1992), S. 808-808 
    ISSN: 0009-286X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Chemie Ingenieur Technik - CIT 66 (1994), S. 1187-1188 
    ISSN: 0009-286X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Chichester [u.a.] : Wiley-Blackwell
    Surface and Interface Analysis 16 (1990), S. 341-346 
    ISSN: 0142-2421
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: TiO2 and CeO2 are will known for inducing strong metal-support interactions J(SMSI) of a different nature when used as supports for Pt catalysts. X-ray photoelectron spectroscopy analysis of mixtures of TiO2—CeO2 oxide supports (80:20 and 20:80) reveals at the surface a remarkable stabilization of cerium in the +3 oxidation state; the stabilization is more pronounced with lower cerium oxide concentration. X-ray absorption spectroscopy measurements done on the LIII edge show the same variation as a function of cerium oxide concentration, but in the bulk the reduction is much lower. Cerium in Pt/TiO2—CeO2 catalysts exhibits the same behaviour.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Chichester [u.a.] : Wiley-Blackwell
    Surface and Interface Analysis 21 (1994), S. 150-154 
    ISSN: 0142-2421
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: We have used work function measurements (Δφ), Auger electron spectroscopy, low-energy electron diffraction and angle-resolved inverse photoelectron spectroscopy to study the coadsorption of barium and oxygen on tungsten. The experimental two-dimensional band structure was compared with results of embedded cluster model calculations for a c(2 × 2) BaO monolayer on W(001) with barium and oxygen placed on alternate fourfold-hollow sites. Our work function measurements revealed that adsorption of one monolayer of BaO decreased the work function of W(001) (φ = 4.63 eV) to ∼ 2.3-2.4 eV regardless of the order of barium and oxygen adsorption on the surface. Inverse photoelectron spectroscopy in the isochromat mode was used to investigate the unoccupied electronic energy levels of one monolayer of BaO on W(001) along two high-symmetry directions of the W(001) surface Brillouin zone. Non-dispersing spectral features were observed at 0.6 eV and 3.4 eV above the Fermi level (EF) and were assigned to transitions into both barium and tungsten d states in good agreement with calculated densities of states.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
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