ISSN:
1432-0533
Keywords:
Microtubule-associated protein-2
;
Somatodendritic distribution
;
Alzheimer's disease
;
Senile plaque neurites
;
Paired helical filaments
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary We have developed monoclonal antibodies that detect normal microtubule-associated protein-2 (MAP2) epitopes in routinely fixed, paraffin-embedded tissue. The somatodendritic distribution of MAP2 in bovine and human nervous tissue was confirmed with several of these antibodies. Furthermore, some of these antibodies immunohistochemically labeled certain pathological structures in Alzheimer brain, especially neurites in senile plaques. Electron microscopic observations, however, indicate that these MAP2 epitopes are not located in the Alzheimer paired helical filaments themselves, but in amorphous granular structures coexistent with them. While the pathological nature of these structures is undetermined, they may represent artefactual modifications of normal cytoskeletal components.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00308477
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