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  • 1
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    Rapid Communications in Mass Spectrometry 5 (1991), S. 618-621 
    ISSN: 0951-4198
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: Negative-ion continuous-flow fast-atom bombardment mass spectroemtry was evaluated asa means for the quantitative analysis of N-acetylneuraminyl-galactosyl-glucosyl ceramide (NeuAc-GM3) and N-acetylgalactosaminyl-(N-acetylneuraminyl)galactosyl-glucosyl-ceramide (NeuAc-GM3). This study was carried out on a 7070-EQ mass spectrometer (VG Analytical, Manchester, UK) using a home-made continuous-flow fast-atom bombardment probe with a mixture of methanol +water+triethanolamine (70:27:3, v/v/v)as the mobile phase. Utilizing 100 ng of acetyl-lysogalactosyl-N-acetylgalactosaminyl-(N-acetylneuraminyl)galactosyl-glucosylceramide (acetyl-lysoGM1) as an internal standard curves for NeuAc-GM3 d18:1-16 0, NeuAc-GM3 d18:1-18:0 and Neuac-GM3 d18:1-18:0 were found to be linear over the range 5-250ng, with associated correlation coefficients of 0.990-0.997. The lower limit of detection was found to be 2.5ng. Satisfactory results could also de obtained when the calibration curves were derived from the deprotonated molecular ions of a mixture of the NeuAc-M2 and NeuAc-GM3 classes. Using this approach, quantitative determination of NeuAc-GM3 d18:1-16:0 from rat adrenal gland was performed sing N-acetylneuraminic acid assay as a test control. We found 278±36 ng of this species in 1 mg of tissue (three replicate experiments). The procedure represents a senstive method for the quantitation of mionosialogangliosides and its capability to give molecular species information.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Stamford, Conn. [u.a.] : Wiley-Blackwell
    Polymer Engineering and Science 32 (1992), S. 724-731 
    ISSN: 0032-3888
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: A methodology is set forth for the numerical solution of the transient freezing problem of a viscous power-law fluid flowing in a cold empty tube with a frozen layer forming on the inside tube surface. The fluid considered is the melt of a semicrystalline polymer with temperature dependent viscosity. The solution domain encompasses both the liquid and solid phases. Coordinate transformations are employed to immobilize and to straighten the moving, curved interface. An implicit finite difference method is employed to solve the governing equations. Numerical results are analyzed by examining the effects of the Peclet number, Nahme number, Stefen number, and the power law index on the profiles of the frozen layer. Variations of the thickness of the frozen layer as a function of time and axial coordinate are also presented.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part B: Polymer Physics 32 (1994), S. 1791-1798 
    ISSN: 0887-6266
    Keywords: alternating poly(ethylene-propylene) (hydrogenated polyisoprene) melts ; pressure-volume-temperature (P-V-T) properties ; density ; specific volume ; equations of state ; Flory-Orwoll-Vrij (FOV) ; Modified Cell Model (MCM) ; Sanchez-Lacombe (SL) ; Statistical Associating Fluid Theory (SAFT) ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The pressure-volume-temperature (P-V-T) properties of monodisperse alternating poly(ethylene-propylene) (hydrogenated polyisoprene) melts of varying molecular weights are measured at 0.1 MPa 〈 P 〈 200.1 MPa, and 290 K 〈 T 〈 510 K in a dilatometer-type apparatus. The Flory-Orwoll-Vrij (FOV), Modified Cell Model (MCM), Sanchez-Lacombe (SL), and the Statistical Associating Fluid Theory (SAFT) equations of state are found to correlate the experimental data with excellent accuracy, except either at low pressures and high temperatures, or at high pressures and low temperatures. On average, MCM and SAFT fit the data slightly better than FOV and SL. The equation-of-state parameters are found to be independent of molecular weight, especially for SAFT, as required by the theory. © 1994 John Wiley & Sons, Inc.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    New York : Wiley-Blackwell
    Biopolymers 29 (1990), S. 335-346 
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Small-angle neutron scattering (SANS) was used to study the structure of protein/sodium dodecylsulfate complexes. Two water soluble proteins, bovine serum albumin (BSA) and ovalbumin (OVA), were used. The protein concentration was kept constant at 1 wt %, and protein/detergent wt ratio varied between 1/1, 1/1.5, 1/2 and 1/3. Absolute intensities of SANS distributions were analyzed by a fractal model. Analyses of large Q portions of SANS distributions established that sodium dodecylsulfate (SDS) molecules bound to a protein/SDS complex form micelle-like clusters. On the other hand, analyses of small Q portions of SANS distributions clearly showed that the arrangement of micelle-like clusters resembles a fractal packing of spheres. We showed that a protein/SDS complex can be characterized by four parameters extracted from the scattering experiment, namely, the average micelle size and its aggregation number, the fractal dimension characterizing the conformation of the micellar chains, the correlation length giving the extent of the unfolded polypeptide chains, and the numbers of micelle-like clusters in the complex.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Stamford, Conn. [u.a.] : Wiley-Blackwell
    Polymer Engineering and Science 31 (1991), S. 191-196 
    ISSN: 0032-3888
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The problem of steady solidification of a power law fluid flowing in a round tube was solved numerically. The fluid considered was a polymer with temperature dependent viscosity. The mathematical solution was obtained by using an implicit finite difference method. Results are presented to show the effects of the Peclet number, Nahme number, and the power law index on the profiles of the frozen layer. Melt temperature profiles at different axial locations are also presented.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Applied Organometallic Chemistry 8 (1994), S. 473-480 
    ISSN: 0268-2605
    Keywords: Inflammation ; amine carboxyboranes ; metal complexes ; HCT-8 toxicity ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The metal complexes and salts of amine carboxyboranes were shown to be potent anti-inflammatory agents in rodents at 8 mg kg-1. They were effective in blocking induced edema, pleurisy and endotoxic shock while blocking both local and central pain processes. The ability of the agents to function as anti-inflammatory agents is multi-fold. First, lysosomal enzymes of specific cells, e.g. macrophages, were inhibited with IC50 values in the range of 10-6 M. Collagenase I and II activities were inhibited with IC50 values approximately equal to 10-4 M. The anti-inflammatory activity of these agents at the molecular levels appears to be due to inhibition of the release of TNFα and Il-1 from macrophages which indirectly control chemotaxic migration of white blood cells as indicated by the suppression of PMN and macrophage invasion into sponges implanted subcutaneously (SC) in mice. Furthermore, in these invading cells, the agents' blockage of TNFα and Il-1 or Il-2 release down-regulates prostaglandin and leukotriene enzymatic synthetic rates and, consequently, their release, resulting in a reduction of the inflammation process.
    Additional Material: 8 Tab.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Hoboken, NJ : Wiley-Blackwell
    Advances in Polymer Technology 12 (1993), S. 361-378 
    ISSN: 0730-6679
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: The Intelligent Processing of Materials (IMP) concept has been applied to the calendering process with the goal of improving shape quality and process efficiency. All four basic features of the IPM, including modeling, data processing, sensing, and controlling, are considered. In the process modeling, bending and thermal models are developed. With these models, the relationship between the process parameters and quality of the calendered sheets has been established. A material data bank has been established to couple with the process modeling and real-time sensing data. In sensing, ultrasonic and temperature sensors have been implemented to measure critical quality and process parameters in situ. The sensing data have been used not only to verify the modeling prediction but also to establish information needed to diagnose the causes of the layflat problem. Based on the model prediction as well as sensing information, a better control system to alleviate layflatness problems has been developed. Finally, a control strategy for future improvement of the calendering system is proposed. © 1993 by John Wiley & Sons, Inc.
    Additional Material: 18 Ill.
    Type of Medium: Electronic Resource
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