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  • 1990-1994  (672)
  • Analytical Chemistry and Spectroscopy  (465)
  • Organic Chemistry  (207)
  • 1
    Electronic Resource
    Electronic Resource
    α-Methylierter Fencholen- und α-Campholenaldehyd - Synthese und Reaktionen (1993)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 335 (1993), S. 687-693 
    Details
    ISSN: 0941-1216
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: α-Methylated Fencholenic and α-Campholenic Aldehyde - Synthesis and ReactionsThe syntheses of α-methylated fencholenic (6a) and α-campholenic aldehyde (6b) via the corresponding azomethines (5) are reported. Aldol condensations of 6a, b with following reductions give the allylic alcohols (12-16) and hydrogenation the saturated alcohols (17-21) with strong woody odors, some of the allylic alcohols resembling that of sandal wood. Simple reduction or oxidation of 6a, b give the alcohols (24, 27), ethers (26), esters (23, 25, 28) and ketones (29) which have interesting woody odors with spicy, earthy and herbaceous notes.
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19933350807
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  • 2
    Electronic Resource
    Electronic Resource
    Kinetic model for acid-catalysed hydrolysis of benzohydroxamic acidPart of this work was reported at the 3rd European Symposium in Organic Reactivity, Goteborg, Sweden, July 1991, paper No. A-13. (1992)
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 5 (1992), S. 39-43 
    Details
    ISSN: 0894-3230
    Keywords: Organic Chemistry ; Physical Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The kinetics of the hydrolysis of benzohydroxamic acid have been investigated in hydrochloric, sulphuric and perchloric acids in 10% (v/v) dimethyl sulphoxide - water at 55 °C. Activation parameters were also determined. Rate correlation by the Cox - Yates excess acidity method shows an A-2 mechanism involving rapid pre-equilibrium protonation of the substrate followed by rate-limiting attack of water at the carbonyl carbon atom to form a tetrahedral intermediate which collapses, in a fast step, to the products.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/poc.610050106
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  • 3
    Electronic Resource
    Electronic Resource
    Identification with liquid chromatography-ionspray mass spectrometry of the metabolites of the enantiomers N-methyl dextrorphan and N-methyl levorphanol after rat liver perfusion (1993)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 22 (1993), S. 226-234 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: To gather more information on stereochemical factors in the hepatic disposition of organic cations, mass spectrometry coupled to liquid chromatography was used to determine the identity of the metabolites excreted in bile after isolated rat liver perfusions with the quaternary ammonium derivatives of the enantiomeric drugs dextrorphan and levorphanol. Ionspray mass spectrometry was chosen for its soft ionization and absence of thermal degradation of labile compounds. The drugs were labelled with a stable (2H) isotope and mixed with unlabelled drugs to create an artificial isotope pattern in the mass spectrum and facilitate the recognition of unknown metabolites. In mass spectra that were recorded under normal conditions, fragmentation was absent and metabolites of N-methyl dextrorphan and N-methyl levorphanol were visible as parent-ion ‘doublets’. Collision-induced fragmentation studies were performed to support the identification of the metabolites. For N-methyl dextrorphan the glucuronide, the glutathione conjugate and the glucuronide of the N-demethylated metabolite were found in bile. For N-methyl levorphanol the glucuronide, the glutathione conjugate, the sulphate conjugate and the glucuronide of a hydroxylated N-methyl levorphanol were excreted in bile. Thus a remarkable stereoselectivity occurs in the metabolism of these quaternary ammonium compounds in the rat liver.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200220403
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  • 4
    Electronic Resource
    Electronic Resource
    Determination of kerosene and light oil components in blood (1991)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 20 (1991), S. 493-497 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A sensitive and rapid method to analyse fuel components in blood from rats exposed to kerosene or light oil vapour was developed by making use of capillary gas chromatography/mass spectrometry. The aliphatic hydrocarbons with carbon numbers 8-10 and aromatics such as toluene, xylene, 3- and 4-ethyltoluene and trimethylbenzenes were clearly detected in blood from rats exposed to kerosene or light oil vapour, using the head-space method combined with the salting-out technique. The concentration ratio of pseudocumene to toluene in blood exposed to light oil was higher than that in the case of exposure to kerosene. The lower limits of detection were 50 pg and 1 ng in toluene and pseudocumene, respectively. Our suggestion is that this method is useful in forensic investigations to detect fuel components in blood and for the purposes of differentiating kerosene and light oil in blood tissues.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200200810
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  • 5
    Electronic Resource
    Electronic Resource
    Synthese, Struktur und Reaktionen des EpoxyfencholenaldehydsHerrn Prof. Dr. Gerhard Werner zum 60. Geburtstag gewidmet. (1993)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 335 (1993), S. 363-367 
    Details
    ISSN: 0941-1216
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Synthesis, Structure and Reactions of Epoxyfencholene AldehydeFencholene aldehyde (2), a by-product of the synthesis of α-campholene aldehyde (1), can be obtained as main product by fenchane rearrangement of pinocarveol. Epoxidation of the protected fencholene aldehyde (3) gives the trans-epoxy-aldehyde (4) which rearranges with Lewis acids to ketone (5) and allylic alcohol (6).
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19933350410
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  • 6
    Electronic Resource
    Electronic Resource
    Synthese eines „Ethyl-Brahmanols“ (1993)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 335 (1993), S. 445-448 
    Details
    ISSN: 0941-1216
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Synthesis of „Ethyl-Brahmanol“The synthesis of the title compound (11) from ethylapopinene (5) by oxydation to the epoxide (6), rearrangement to “ethyl-α-campholene aldehyde” (7) and its aldol condensation is described.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19933350509
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  • 7
    Electronic Resource
    Electronic Resource
    Synthese und Reaktionen von β-Campholenverbindungen (1993)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 335 (1993), S. 537-543 
    Details
    ISSN: 0941-1216
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Synthesis and Reactions of β-Campholene CompoundsIn contrast to the well known α-campholenic (B) and fencholenic compounds (C) little is known about β-campholenic derivatives (A) because of their difficult accessibilitiy. β-Campholenic compounds (A) can be obtained: (1) by Baeyer-Villiger oxidation of camphor via lactone 7 and β-dihydrocampholenic lactone (5); (2) by Beckmann fragmentation of camphor oxime via α-(2) and β-campholenic nitril (3) and the lactone 5; and (3) by acid catalysed rearrangement of α-campholenic derivatives (B, 17a, b). The β-analogous brahmanol (14) can be synthesized by the reaction of the β-campholenic bromide (11) with methyl diethyl malonate or by rearrangement of brahmanol.
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19933350607
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  • 8
    Electronic Resource
    Electronic Resource
    The use of tandem mass spectrometry as a problem-solving tool in the industrial environment (1990)
    New York, NY : Wiley-Blackwell
    Rapid Communications in Mass Spectrometry 4 (1990), S. 454-460 
    Details
    ISSN: 0951-4198
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: This paper deals with a number of the benefits associated with a variety of tandem mass spectrometer geometries and the way in which these configurations have been applied to the solution of real problems. It discusses the use made of a variety of tandem mass spectrometry approaches to the study of analytical problems of industrial relevance. ICIs utilization of tandem mass spectrometry has grown substantially from an initial involvement in the early 1980s to a point where a number of instruments have been installed and used predominantly for trace analysis, structural studies and in the characterization of complex mixtures. We have selected a small number of examples of the use of the various tandem mass spectrometry approaches emphasizing the unique features of the technique.
    Additional Material: 17 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/rcm.1290041025
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  • 9
    Electronic Resource
    Electronic Resource
    In vitro hydrolysis of RR,SS-threo-methylphenidate by blood esterases - differential and enantioselective interspecies variability (1991)
    New York, NY [u.a.] : Wiley-Blackwell
    Chirality 3 (1991), S. 99-103 
    Details
    ISSN: 0899-0042
    Keywords: methylphenidate ; enantioselectivity ; blood esterases ; hydrolysis ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Enantioselective in vitro hydrolysis of methylphenidate (MPH) by the blood esterases of seven mammalian species is reported. The species included rats, rabbits, dogs, cattle, horses, monkeys, and humans. In vitro incubations up to 8 h were carried out in plasma, red blood cells, and whole blood of the various species. Enantioselective differences were evident among the different species on comparison of the data obtained from the three biological fluids. The esterases present in plasma appeared to show greater activity in the hydrolysis of MPH in all species where comparison with the other two biofluids was possible. Only in the case of humans did esterases present in plasma and red blood cells demonstrate opposite enantioselectivity in the hydrolysis of MPH. Thus after 8 h incubation, the RR-MPH/SS-MPH ratios in plasma and red blood cells were 0.31 and 1.16, respectively.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/chir.530030204
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  • 10
    Electronic Resource
    Electronic Resource
    Neue makrocyclische Wirte für den Einschluß von organischen Gastmolekülen - Kristallstruktur eines Komplexes mit Dimethylformamid (1 : 1) (1993)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 335 (1993), S. 235-243 
    Details
    ISSN: 0941-1216
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: New Macrocyclic Hosts for the Inclusion of Organic Guest Molecules - Crystal Structure of a Complex with Dimethylformamide (1 : 1)New pyridino crowns with amide and sulfonamide groups 1b and 1c are synthesized. They form numerous stoichiometric crystalline inclusion complexes with alcohols, various dipolar-aprotic solvents, as well as cyclic ethers. Host-guest stoichiometries are discussed and inclusion selectivities (relating to DMF) are shown. The structure of the crystalline DMF inclusion compound of the sulfonamide host 1c (1 : 1) is determined by X-ray diffraction, showing a lattice void inclusion mode.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19933350305
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