ISSN:
1619-7089
Keywords:
Radionuclide generator
;
Zinc-62
;
Copper-62
;
Pyruvaldehyde-bis(N4-methylthiosemicarbazone)
;
PTSM
;
Positron emission tomography
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Clinical utilisation of positron emission tomography could be enhanced by the availability of shortlived radionuclides derived from generator systems. The zinc-62/copper-62 combination is one such system which could be used as a source for a number of copper-62 radiopharmaceuticals. We have developed and optimised a high activity (5.6 GBq, 150 mCi) zinc-62/copper-62 generator to provide 62CU in a form that is suitable for direct labelling of pyruvaldehyde-bis-(N 4-methylthiosemicarbazone)-copper(II), Cu(PTSM). The distribution coefficients of Zn(II) and Cu(II) between anion-exchange resin and various hydrochloric acid/organic solvent mixtures were measured. Based on these measurements a generator eluent of 0.3 M HCl/40% ethanol provided 62CU in 〉90% yield in a 3-ml volume. A very low 62Zn breakthrough of less than 3×10−7% was achieved. Copper-PTSM was successfully labelled with the no-carrier-added 62Cu eluent directly from the generator with 94% radiochemical yield.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00177368
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