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  • 1990-1994  (2)
  • Anthropométrie  (1)
  • Escherichia coli C  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European spine journal 1 (1992), S. 38-42 
    ISSN: 1432-0932
    Keywords: Muscles paravertébraux ; Muscle multifide ; Anthropométrie ; Lombalgie ; Paraspinal muscles ; Multifidus ; Anthropometry ; Low back pain
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary This study of 52 patients (27 men) with recent (18 months) or chronic (〉18 months) low back and unilateral radicular pain symptoms was undertaken to investigate whether wasting of the paraspinal muscle components is generalised or selective. During the patients' routine computed tomographic lumbar spinal scans a standardised transaxial view was obtained along the upper end-plate of the L4 vertebra, and the cross-sectional areas of the paraspinal muscles and their components, multifidus and erector spinae, estimated. Irrespective of whether the symptoms were recent or chronic, multifidus dimensions were significantly greater on the side ipsilateral to the radicular pain symptoms. The results indicate selective changes of multifidus in these patients and possibly reflect an adaptive response by this muscle, such as to an increased role in stabilising the lumbar spine in the face of overall paraspinal muscle atrophy.
    Notes: Résumé Cette étude a été réalisée chez cinquante deux patients (27 hommes, 25 femmes), présentant une lombalgie soit récente (depuis moins de 18 mois), soit chronique (depuis plus de 18 mois) associée à une radiculalgie unilatérale. Le but de la recherche était de déterminer si l'atrophie des muscles paravertébraux était globale ou élective. Lors de l'examen scannographique de routine pratiqué chez ces patients, une coupe transversale a été pratiquée le long du plateau supérieur de la 4e vertèbre lombaire, permettant d'évaluer l'étendue de la surface occupée par ces muscles paravertébraux et leurs composants, plus particulièrement le muscle multifide et le muscle érecteur du rachis. Les résultats indiquent des modifications électives du muscle multifide chez les patients porteurs de lombalgies, et réflètent vraisemblablement une réponse adaptative de ce muscle qui semble jouer un rôle accru dans la stabilisation du rachis lombaire face à l'atrophie globale des muscles paravertébraux.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1617-4623
    Keywords: Aromatic acid catabolism ; Escherichia coli C ; Cloned genes ; Pathway organization ; Sequencing hpcR
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Homoprotocatechuate (HPC; 3,4-dihydroxyphenylacetate) is catabolized to Krebs cycle intermediates via extradiol (meta-) cleavage and the necessary enzymes are chromosomally encoded in a variety of bacteria. Based on an analysis of the cloned pathway genes, the Escherichia coli C hpc gene cluster was thought to be arranged in two gene blocks transcribed from a central, divergent, operator/promoter region, which was negatively regulated by the Hpc repressor. By a variety of techniques including expression of cloned hpc genes in pUC18/19 vectors, unidirectional deletion subcloning, hybridization studies and nucleotide sequencing it has now been shown that the hpc pathway structural genes are transcribed in one direction. These experiments have also indicated that a decarboxylase and an isomerase of the pathway are encoded by a single gene (hpcE) and have established the exact structural gene order as hpcRphpcECBDGH. The position of the putative regulatory gene, hpcR, is upstream of the first structural gene (hpcE) for the Hpc pathway enzymes. The deduced open reading frame for the Hpc repressor specifies a protein of 148 amino acids with a subunit molecular weight of 17 kDa. The region between hpcR and the first gene for the pathway enzymes has a sequence similar to that for catabolite activator protein (CAP) binding. This region is immediately upstream of a promoter for the pathway structural genes, which has been identified by transcript mapping.
    Type of Medium: Electronic Resource
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