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  • 1990-1994  (2)
  • Autoclaving  (1)
  • dopamine  (1)
  • PPi; inorganic pyrophosphate
  • 1
    Electronic Resource
    Electronic Resource
    Cranioplasty with a frozen and autoclaved bone flap (1990)
    Springer
    Acta neurochirurgica 102 (1990), S. 38-41 
    Details
    ISSN: 0942-0940
    Keywords: Autoclaving ; autogenous bone graft ; cranioplasty ; freezing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 27 cases of cranioplasty with autogenous bone grafts stored in a deep-freezer and autoclaved before use are reported. The results of follow-up for an average period of one year were satisfactory from the standpoint of brain protection and cosmetic reconstruction. A small area of absorption of grafted bone was observed in two cases on the follow-up skull roentgenograms. No serious complications were seen except in one case, whose bone flap had to be removed due to an epidural abscess. Experiments revealed that deep-freezing and autoclaving had only minimal effects on bone structure, although osteocytes degenerated. Autogenous bone flap after deep-freezing is a useful material for cranioplasty but sterilization before use is indispensable. Autoclaving is a simple method for sterilization of the flap, available in any operating theatre. It does not increase the risk of postoperative complications such as infection or absorption.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01402184
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Competitive and noncompetitive N-methyl-D-aspartate antagonists protect dopaminergic and serotonergic neurotoxicity produced by methamphetamine in various brain regions (1993)
    Springer
    Journal of neural transmission 92 (1993), S. 97-106 
    Details
    ISSN: 1435-1463
    Keywords: Methamphetamine ; neurotoxicity ; N-methyl-D-aspartate ; dopamine ; serotonin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Protective effects of NMDA antagonists on dopaminergic and serotonergic neurotoxicity produced by methamphetamine (MA) were examined. Four injections of MA (7.5 mg/kg, s.c., at 2 h intervals) caused significant decrements (40–60% of control values) in levels of dopamine (DA) and its metabolites in the rat striatum and levels of serotonin (5-HT) and its metabolite in the medial prefrontal cortex, nucleus accumbens, striatum, anterior hypothalamus, amygdala and hippocampus. These decreases in DA, 5-HT and their metabolites were prevented by pretreatment with MK-801, a noncompetitive N-methyl-D-aspartate (NMDA) antagonist, or D-CPP-ene (SDZ EAA 494), a competitive NMDA antagonist. The results suggest that NMDA receptors play a role for MA-induced serotonergic damage in various brain regions as well as dopaminergic damage in the striatum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01244869
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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