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  • 1990-1994  (2)
  • Brain
  • Engineering General
  • GASTRIC ELECTRICAL ACTIVITY
  • MK-801
  • 1
    Electronic Resource
    Electronic Resource
    The distribution of neuropeptide Y and dynorphin immunoreactivity in the brain and pituitary gland of the platyfish, Xiphophorus maculatus, from birth to sexual maturity (1993)
    Springer
    Cell & tissue research 271 (1993), S. 87-92 
    Details
    ISSN: 1432-0878
    Keywords: Neuropeptide Y ; Dynorphin ; Brain ; Pituitary ; Sexual maturation ; Xiphophorus maculatus (Teleostei)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Immunoreactive neuropeptide Y and dynorphin have been localized in the brain and pituitary gland of the platyfish, Xiphophorus maculatus, at different ages and stages of development from birth to sexual maturity. Immunoreactive neuropeptide Y was found in perikarya and tracts of the nucleus olfactoretinalis, telencephalon, ventral tegmentum and in the neurohypophysis and in the three regions of the adenohypophysis. Immunoreactive dynorphin was found in nerve tracts in the olfactory bulb and in cells of the pars intermedia and the rostral pars distalis of the pituitary gland.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00297545
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    On the roles of dopamine D-1 vs. D-2 receptors for the hyperactivity response elicited by MK-801 (1994)
    Springer
    Journal of neural transmission 95 (1994), S. 113-121 
    Details
    ISSN: 1435-1463
    Keywords: NMDA receptors ; DA receptors ; MK-801 ; SCH 23390 ; raclopride ; locomotor activity ; schizophrenia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The present study was aimed at clarifying to what extent the hypermotility induced by the uncompetitive N-methyl-D-aspartate (NMDA) antagonist MK-801 depends on dopamine (DA) D-1 compared to D-2 receptor tone. The D-1 receptor antagonist SCH 23390 was found to reduce locomotion to a greater extent in MK-801-treated than in vehicle-treated mice, whereas the reverse appeared to be the case for the DA D-2 receptor antagonist raclopride. In other words, MK-801-induced hyperactivity was more readily antagonized by SCH 23390 than by raclopride and, thus, DA D-1 receptors seem to be more important than D-2 receptors for MK-801-induced hyperactivity. These results are in line with our previous observation that MK-801 generally interacts synergistically with a DA D-1 but not with a D-2 receptor agonist in monoamine-depleted mice. In view of the possible role of deficient glutamatergic neurotransmission in schizophrenia, our findings underline the importance of investigating the efficacy of selective DA D-1 antagonists in this disorder.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01276430
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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