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  • 1990-1994  (2)
  • Calliphora vicina  (1)
  • Sodium channel  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Phase shifts of the adult locomotor activity rhythm in Calliphora vicina induced by non-steroidal ecdysteroid agonist RH 5849 (1993)
    Springer
    Journal of comparative physiology 172 (1993), S. 101-108 
    Details
    ISSN: 1432-1351
    Keywords: Calliphora vicina ; Circadian rhythms ; Phase response curve ; RH 5849 ; Ecdysteroids ; Computer modelling
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract RH 5849, a non-steroidal ecdysteroid mimic, was found to cause consistent phase shifts in the circadian rhythm of locomotor activity of the blowfly, Calliphora vicina. This compound causes phase advances in the early subjective night and phase delays in the late subjective night. This effect is the opposite, but not the mirror image of the phase response curve obtained for 1 h light pulses. This suggests that ecdysteroids might act as entraining agents via the output pathway by feedback to “clock” neurons in the brain. A computer model based on 12 pacemaker neurons with circadian periods (τ values) from short to long without simulated feedback from the ecdysteroid system becomes arrhythmic; with feedback, the oscillators become synchronized to a common period. The possible role of ecdysteroids as endogenous synchronizing agents in the insect circadian system is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00214719
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Inhibition of the sodium channel by SK&F 96365, an inhibitor of the receptor-operated calcium channel, in mouse diaphragm (1994)
    Springer
    Journal of biomedical science 1 (1994), S. 172-178 
    Details
    ISSN: 1423-0127
    Keywords: SK&F 96365 ; Crotamine ; Calcium channel blocker ; Local anesthetic ; Sodium channel
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The effects of SK&F 96365, a blocker of the receptor-operated Ca2+ channel, on contractilities and the Na+ channel of mouse diaphragm were studied. SK&F 96365 (10–50 µM) reversibly inhibited twitches, tetanic contractions and muscle and nerve action potentials. The IC50 was 17–24 µM. The inward Na+ current was suppressed and its recovery from inactivations delayed. Crotamine, a peptide toxin that binds to neurotoxin receptor site 3 of the muscle Na+ channel, enhanced the inhibitory effects of SK&F 96365 and reduced the IC50 to about 4 µM. Veratridine had similar effects, although it was less effective than crotamine. On the other hand, the crotamine-induced membrane depolarizations and spontaneous discharges of muscle action potentials were inhibited by SK&F 96365 noncompetitively. The inhibitory effects of tetrodotoxin and tetracaine were additive with those of SK&F 96365 but were enhanced slightly by crotamine. The results suggested that SK&F 96365 acts on a distinct site and blocks the Na+ channel of excitable membranes at a concentration range that inhibits the receptor-operated calcium channel.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02253347
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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