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Digitale Medien

On-line solution stability determination of pharmaceuticals by capillary electrophoresis (1993)

Altria, K. D. ; Connolly, P. C.

Springer

Chromatographia 37 (1993), S. 176-178

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Details

ISSN: 1612-1112

Schlagwort(e): Capillary electrophoresis ; Stability testing ; Ranitidine related impurities

Quelle: Springer Online Journal Archives 1860-2000

Thema: Chemie und Pharmazie

Notizen: Summary Good agreement between the impurity levels in a batch of a related impurity of ranitidine were obtained by CE and HPLC. A solution of the impurity was positioned on the CE autosampler and analysed sequentially. The extent of degradation was monitored by loss of main peak and the formation of two principal degradation products. It was found that after 9.25 hours only 2% area/area of the original impurity remained. Buffering of the sample solution to pH 7 was shown to minimise this degradation. Unattended in-situ stability testing of an solution of the impurity in water was performed by CE.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF02275857

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