ISSN:
1432-1440
Keywords:
Finger nailfold
;
Capillary microscopy
;
Nailfold biopsy
;
Capillary deformity
;
Collagen deposition
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Quantitative finger nailfold capillary microscopy was performed in 25 patients with type I diabetes and in 27 healthy control subjects. In the last consecutive 6 patients and 7 controls of these populations, finger nailfold biopsies were taken. Measurements of loop width as an in vivo parameter for deformities of the capillary loops showed significantly higher values in diabetic patients than in controls. Histopathological examination showed markedly and significantly increased deposition of collagen in nailfold dermal papillae of the diabetic patients. The deposition of collagen was positively correlated with the number of capillary endothelial cells in the nailfold dermal papillae and with the size of the papillae in diabetic patients. It is concluded that, in addition to deformity of nailfold capillaries, collagen deposition may also be a sign of metabolic disturbance and perhaps of proliferation of capillary endothelial cells in diabetic microangiopathy.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01649455
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