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  • 1990-1994  (2)
  • Carbamazepine  (1)
  • Facial nerve  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Carbamazepine-induced skin rash in children with epilepsy (1993)
    Springer
    European journal of pediatrics 152 (1993), S. 605-608 
    Details
    ISSN: 1432-1076
    Keywords: Carbamazepine ; Adverse reactions ; Epilepsy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The clinical and epidemiological findings in children with epilepsy who experienced skin rashes induced by carbamazepine (CBZ) were prospectively evaluated. Thirty-three (9.9%) of 335 patients who received CBZ therapy experienced a skin rash. Seven had diffuse erythema, 13 miliary exanthema, 11 maculopapular or speckled reddish rash, 3 petechiae, and 2 mucocutaneous syndrome. A skin rash was more frequent in older children (over 6 years old). The skin rashes appeared soon after initiation of the therapy, i.e., from the 8th to 60th day (mean: 14.3±9.6 days) after the start of CBZ therapy and disappeared within a few days after discontinuation of the therapy. Haematological abnormalities (30.3%), such as leucocytopenia and thrombocytopenia, and hepatic dysfunction (27.3%) sometimes appeared concomitantly with the skin rash. CBZ is an effective and safe antiepileptic drug, but careful management is necessary on initiation of the therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01954091
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Ultracytochemical demonstration of ouabain-sensitive, K+-dependent,p-nitrophenylphosphatase (Na-K ATPase) activity in cat facial nerve (1994)
    Springer
    European archives of oto-rhino-laryngology and head & neck 251 (1994), S. 238-240 
    Details
    ISSN: 1434-4726
    Keywords: Potassium-dependent ; p-nitrophenylphosphatase ; Facial nerve ; Cerium-based-enzymology ; Ultracytochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Ouabain-sensitive, K+-dependent,p-nitrophenylphosphatase (K-NPPase) is the second dephosphorylative property of the Na-K ATPase complex. Localization of its activity in the horizontal portion of the facial nerve in 11 normal cats was studied ultracytochemically using a cerium-based method. The fine granular reaction product of the K-NPPase activity was observed on the cytoplasmic side of the axolemma of the axon cylinder. Enzyme activity was also detected on the cytoplasmic side of the plasma membrane of Schmidt-Lanterman incisures and nodes of Ranvier. No reaction product was detected on the periaxonal and outermost plasma membrane of Schwann cells and in the myelin sheath. In control tissue samples, enzyme activity was almost completely inhibited by 10 mM ouabain, and no reaction was noted in medium without K+. The present findings indicate that localization of Na-K ATPase in the cat facial nerve simulates that of other peripheral and cranial nerves.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00628431
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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