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  • 1
    Electronic Resource
    Electronic Resource
    Seroquel: behavioral effects in conventional and novel tests for atypical antipsychotic drug (1993)
    Springer
    Psychopharmacology 112 (1993), S. 299-307 
    Details
    ISSN: 1432-2072
    Keywords: Seroquel ; ICI 204,636 ; Atypical antipsychotic ; Tardive dyskinesia ; Novel tests ; Cebus monkeys ; Swimming normalization test
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Seroquel was compared to clozapine and several other antipsychotic agents in tests predictive of antipsychotic activity or extrapyramidal symptoms. In the conditioned avoidance test in squirrel monkeys as well as several paradigms using apomorphine or amphetamine-induced behavioral alterations, seroquel displayed the profile of a drug with potential antipsychotic activity. In these paradigms the potency of seroquel was somewhat less than clozapine in rodent tests, while the reverse was true in higher species, i.e. monkeys, cats. In tests designed to evaluate the propensity to induce EPS or tardive dyskinesia, for example, the production of dyskinetic reactions in haloperidol-sensitized cebus monkeys, seroquel displayed a profile similar to clozapine and disparate from typical antipsychotic drugs. In drug-naive cebus monkeys seroquel sensitized significantly fewer monkeys than haloperidol and the dyskinetic reactions were of significantly less intensity. It is anticipated that this novel antipsychotic agent will have a significantly reduced propensity to produce extrapyramidal symptoms and tardive dyskinesia than typical antipsychotics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02244925
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  • 2
    Electronic Resource
    Electronic Resource
    Redox processes in polyaniline thin film studied by optical multichannel analysis (1992)
    Chichester [u.a.] : Wiley-Blackwell
    Surface and Interface Analysis 19 (1992), S. 27-32 
    Details
    ISSN: 0142-2421
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: Optical multichannel analysis (OMA) was used to follow the kinetics of colour changes in electrochromic polyaniline films when the latter are polarized in an electrolytic medium at different potentials. These colour changes, which are related to the transition from one polymer form to another, are very fast. OMA also allowed us to obtain an apparent value of the film absorption coefficient. In the investigated range (300-800 nm), several absorption phenomena can be displayed which are characteristic of the different polymer forms. Two electrolytic media (1 M HCl and 1 M H2SO4) were compared to investigate the role played by the size of the inserted counter-ion. The overall results allow us to estimate the practical possibility of using polyaniline in electrochromic devices.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/sia.740190109
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    Paper (German National Licenses)
    Fulltext
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