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Molecular genetics of chimpanzee Rh-related genes: Their relationship with the R-C-E-F blood group system, the chimpanzee counterpart of the human rhesus system (1994)

Salvignol, I. ; Blancher, A. ; Calvas, P. ; [et al.]

Springer

Biochemical genetics 32 (1994), S. 201-221

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ISSN: 1573-4927

Keywords: Rh-related gene ; R-C-E-F system ; molecular genetics ; Southern blot ; phylogeny ; sequences

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Chemistry and Pharmacology

Notes: Abstract As the chimpanzee R-C-E-F blood group system appears to be the chimpanzee counterpart of the human Rhesus (RH) system, we have tried to determine whether chimpanzee Rh-like genes encode R-C-E-F-related proteins. Chimpanzee genomic DNA, digested by any of eight endonucleases and hybridized with three Rh exon-specific probes, exhibits a high degree of polymorphism. Analysis of DNA from unrelated individuals of different R-C-E-F types revealed that the presence of some restriction fragments is correlated with particular R-C-E-F types. The cosegregation of these fragments with R-C-E-F haplotypes was confirmed by family studies. Oligonucleotides complementary to regions flanking human exons were used as PCR primers on chimpanzee DNA; the resulting amplified fragments were identical in size to their human counterparts. Moreover, the nucleotide sequences of the fragments present a high degree of similarity to the corresponding human regions.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00554623

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Brownian dynamics of sterically-stabilized colloidal suspensions (1994)

TeGrotenhuis, Ward E. ; Radke, Clayton J. ; Denn, Morton M.

Hoboken, NJ : Wiley-Blackwell

AIChE Journal 40 (1994), S. 283-293

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ISSN: 0001-1541

Keywords: Chemistry ; Chemical Engineering

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology

Notes: Using Brownian dynamics, equilibrium and dynamic properties are calculated for colloidal suspensions that are stabilized throug the Milner, Witten and Cates (1988) steric potential. Results are reported for osmotic pressure, radial distribution functions, static structure factors, and self-diffusion coefficients. The sterically-stabilized systems are also approximated by equivalent hard spheres, with good agreement for osmotic pressure and long-range structure. The suitability of the potential to model the behavior of a real system is explored by comparing static structure factors calculated from Brownian dynamics simulations to those measured using SANS (Markovic et al., 1986). Finally, the effects of Hamaker and hydrodynamic forces on calculated properties are investigated.

Additional Material: 8 Ill.