ISSN:
1432-1238
Keywords:
ARDS
;
Hydroxyethyl starches
;
Neutrophil
;
Endothelium
;
Adhesion molecules
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Objective To study the effect of medium molecular weight hydroxyethyl starches on endothelial cell and neutrophil activation in vitro.f Setting Laboratory analysis. Methods The effects of albumin and hydroxyethyl starch on the neutrophil adhesion molecule (CD11bCD18), with and without liposaccharide stimulation, were studied in whole blood. E-selection expression on human umbilical vein endothelial cells was stimulated with lipopolysaccharide alone and in the presence of either albumin or hydroxyethyl starch. The effect of albumin and hydroxyethyl starches on rapid endothelial cell activation was studied using von Willebrand factor release as a marker. Measurements and results Hydroxyethyl starches but not albumin inhibited stimulated vWF release in a dose dependent manner. No effect was seen on endothelial Eselectin or neutrophil CD11bCD18 expression. Conclusions These results suggest a possible beneficial role of hydroxyethyl starches in the inhibition of endothelial activation thus preventing neutrophil adhesion during sepsis syndrome.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02425053
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