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Role of central versus peripheral opioid receptors in analgesia induced by repeated administration of opioid antagonists (1991)

Katharine Walker, M. J. ; Lê, A. D. ; Poulos, Constantine X. ; [et al.]

Springer

Psychopharmacology 104 (1991), S. 164-166

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ISSN: 1432-2072

Keywords: Quaternary naltrexone ; CNS opioid receptors ; Analgesia ; Hot plate testing ; Rat

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Although analgesia induced by blockade of opioid receptors has been well established, it is still unknown whether its development is mediated by the blockade of centrally located opioid receptors. Therefore, rats were treated with either systemically or ICV applied naloxone or quaternary naltrexone (QN), an opioid antagonist that does not easily penetrate the blood-brain barrier. Following antagonist administration, each animal was tested for paw lick latency on a 51° C hot plate. Hot plate testing and drug injections were carried out for 4 consecutive days. Rats treated with ICV microinjections of QN or naloxone displayed paw lick latencies that were significantly longer than those observed in control animals. In contrast, rats treated with SC injections of QN did not show any increase in paw lick latency, whereas rats treated with SC injections of naloxone displayed paw lick latencies that were significantly longer than those of control rats. These results are consistent with the hypothesis that the blockade of central opioid receptors underlies the development of an analgesic response.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF02244172

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Photoemission study of an AuPdAu(111) multilayer grown by MBE (1993)

Cole, R. J. ; Evans, J. A. ; Gregory, D. A. C. ; [et al.]

Chichester [u.a.] : Wiley-Blackwell

Surface and Interface Analysis 20 (1993), S. 919-922

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ISSN: 0142-2421

Keywords: Chemistry ; Polymer and Materials Science

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Physics

Notes: An au/Pd/Au(111) multilayer system grown by molecular beam epitaxy has been studied by high-resolution x-ray photoelectron spectroscopy. An analysis of the dependence of the relative intensity of the Au and Pd core-level XPS lines on the take-off angle indicates that the thickness of the Pd sandwhich layer is ∼5 monolayers. The photoelectron spectra show the presence of more than one chemical environment for each element and suggest that the core-level photoelectron spectra of Pd atoms in the interfacial layers and the inner layers of the Pd sandwich are split by ∼0.6 eV. The photoelectron spectra of the valence band show that the Pd sandwich retains the high density of states at the Fermi energy that is characteristic of Pd metal.

Additional Material: 4 Ill.