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  • 1990-1994  (2)
  • Chemistry  (1)
  • principal component regression (PCR)  (1)
  • 1
    Electronic Resource
    Electronic Resource
    A Drug Dissolution Monitor Employing Multiple Fiber Optic Probes and a UV/Visible Diode Array Spectrophotometer (1994)
    Springer
    Pharmaceutical research 11 (1994), S. 979-983 
    Details
    ISSN: 1573-904X
    Keywords: drug dissolution ; fiber optic probes ; UV/Visible diode array spectrometer ; principal component regression (PCR) ; Fourier transform
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract A traditional dissolution pumping system was recently replaced with a fiber optic interface between the spectrometer and the samples. However, the system was limited to a single sample vessel. In this study, a dissolution testing system with six vessels connected to a diode array spectrometer via six optical fibers was investigated. A bifurcated fiber optic bundle was used to transfer the light from the source to the dissolution vessels and was networked so that spectra of each sample can be measured periodically. A full spectrum calibration method based on Principal Component Regression (PCR) was used to determine the concentrations of active ingredients and to account for interferences due to excipients in tablet formulations. Results on this new fiber optic interface system are compared with those obtained previously with the traditional pumping system. Standard errors of prediction are between 1.5 and 3.2% using cross-validation and between 1.1 and 1.7% for the direct validation of two active ingredients in two different drug formulations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018975002025
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    New crown ether resins prepared by cationic template polymerization (1994)
    Weinheim : Wiley-Blackwell
    Macromolecular Chemistry and Physics 195 (1994), S. 391-399 
    Details
    ISSN: 1022-1352
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The synthesis of several dibenzo-18-crown-6 derivatives, and their acid catalyzed incorporation into crosslinked styrene and 4-methoxystyrene based copolymers is described. Some of these reactions were carried out in the presence of chiral ammonium cations acting as non-covalent templates. The polymers have been characterized by IR, and by 1H and 13C solution state and magic angle spinning NMR.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/macp.1994.021950201
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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