ISSN:
0941-1216
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Biochemical studies on mode of action enable the chemist to optimize biologically active chemical structures. As a case study we describe the optimization process of fungicides inhibiting sterol biosynthesis. The spiroketalamines obtained represent new chemicals with various modes of action on sterol biosynthesis. These examples demonstrate that biochemixal studies allow directed pesticide design. The value of biochemistry in pesticide discovery has to be seen in a stepwise optimization rather than in “de-novo”-design.
Additional Material:
4 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/prac.19933350702
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