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The influence of chronic nicotine treatment on stress-induced gastric ulceration and emptying rate in rats (1992)

Qiu, B. S. ; Cho, C. H. ; Ogle, C. W.

Springer

Cellular and molecular life sciences 48 (1992), S. 389-391

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ISSN: 1420-9071

Keywords: Nicotine ; cold-restraint stress ; gastric ulcers and motility

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Abstract Ten-day treatment with nicotine, (5, 25 or 50 μg/ml drinking water) dose-dependently intensified gastric ulceration induced by cold-restraint, and emptying rate. Stomach contractions produced by graded doses of bethanechol i.v. were elevated further by nicotine treatment. It is suggested that chronic nicotine administration produces hypersensitivity of the gastric muscarinic receptors; stomach hypermotility contributes to the ulcer-worsening action of the alkaloid

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01923437

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