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A Structured–Activity Relationship Study of Batracylin Analogues (1993)

Luo, Yilin ; Ren, Yun-Feng ; Chou, Ting-Chao ; [et al.]

Springer

Pharmaceutical research 10 (1993), S. 918-923

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ISSN: 1573-904X

Keywords: isoindolo[l,2-b]quinazolines ; cytotoxicity ; DNA topoisomerase ; colon adenocarcinoma 38 ; structure–activity relationship

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology

Notes: Abstract A number of isoindolo[l ,2-b]quinazolines and some benzo[4,5]isoquinolino[l,2-b]quinazolines as structural modification analogues of the antitumor compound batracylin were synthesized and evaluated against HL-60 cell growth and in topoisomerase II-mediated DNA cleavage assays. Of the compounds studied, 10,12-dihydro-7,8-methy lenedioxyisoindolo[ 1,2-b] quinazolin-12(10H)-one (1d), 2-amino-10,12-dihydroisoindolo[l ,2-b]quinazolin- 12(10H)-one (1p), and 2-amino-7,8-methylenedioxy-10,12-dihydroisoindolo[l ,2-b]quinazolin-12(10H)-one (1ab) exhibited good inhibitory activities against HL-60 cell lines as well as induction of topo II-mediated DNA cleavage activities.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1023/A:1018929815422

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In vitro fertilization, development, and implantation after exposure of mature mouse oocytes to visible light (1992)

Barlow, P. ; Puissant, F. ; Van Der Zwalmen, P. ; [et al.]

New York, NY [u.a.] : Wiley-Blackwell

Molecular Reproduction and Development 33 (1992), S. 297-302

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ISSN: 1040-452X

Keywords: Light exposure ; Implantation rate ; IVF ; Life and Medical Sciences ; Cell & Developmental Biology

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Biology

Notes: Mature mouse oocytes were exposed prior to in vitro fertilization to visible light during 1, 2, or 4 hr at an intensity of 4,000 lux. Compared to controls cultured under identical conditions but protected from light, exposed eggs did not show any significant modification of cleavage speed are rate. After transfer of blastocysts obtained in vitro in uteri of pseudopregnant females, the implantation rate and the proportion of normal fetuses were not found to be different in relation to preliminary light exposure of oocytes fertilized and cultured in vitro. © 1992 Wiley-Liss, Inc.

Additional Material: 1 Ill.