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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 151 (1992), S. 321-325 
    ISSN: 1432-1076
    Keywords: Short stature ; Somatomedin-C ; IGF-I ; IGF-I resistance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report on a Japanese girl with short stature, malar hypoplasia, up-slanting palpebral fissures, blue sclerae and thin, stiff and slightly brownish hair. Short stature started in utero and her psychomotor development was normal. Menarche appeared at 13 years 8 months. Height at 14 years 5 months was 132 cm (−4.6 SD). Her growth hormone (GH) sleep pattern and responses to insulin,l-dopa, arginine, propranolol-glucagon and growth hormone-releasing hormone were normal. Plasma insulin-like growth factor I (IGF-I) was high (2170–4860 units/l) and increased from 4860 to 7080 units/l 20 h after biosynthetic GH injection. Gel infiltration patterns of the free and protein-bound IGF-I in plasma from the patient were not different from the controls; IGF-I fraction of the high and low molecular weight binding protein and the non-protein bound fraction were 75.5%, 15.8% and 8.7%, respectively. IGF-I from the patient showed normal bioactivities when determined by [35S]sulphate and [3H]thymidine uptake into cultured rat chondrocytes, and by [3H]thymidine and [3H]α-aminoisobutyric acid uptake into the patient's skin fibroblasts. IGF-I binding to cultured skin fibroblasts from the patient was comparable to that of controls. These results suggest that tissue specific defects of IGF-I receptors may be the cause of increased IGF-I levels in the patient.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Communications in Applied Numerical Methods 7 (1991), S. 173-186 
    ISSN: 0748-8025
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: Finite-volume calculations of laminar separated flow around a fence are presented using a non-staggered grid system. Using the pressure-weighted interpolation method (PWIM), the role of the under-relaxation factor in this method has been studied. The performance of two pressure-velocity coupling algorithms, viz. SIMPLE and PISO, have been compared as well as the solution fields obtained using non-staggered and staggered grids. A detailed study has been conducted to investigate the occurrence of physically unrealistic convective velocities in the solution fields.The numerical results show that solutions obtained using non-staggered grids are as accurate as those obtained using staggered grids. The presence of very small under/overshoots in the estimated convective fluxes is related to the simultaneous presence of high Péclét numbers and rapidly varying pressure gradients. However, for the complex separated flow investigated, no induced errors were detected in the solution field.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 16 (1993), S. 403-419 
    ISSN: 0271-2091
    Keywords: Outflow boundary conditions ; Laminar recirculating flows ; Non-staggered grid systems ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Several open boundary conditions (OBCs) are compared and evaluated in the framework of the SIMPLE algorithm using staggered and non-staggered grid systems. The benchmark laminar flow test cases used for the OBC evaluation are Poiseuille-Benard flow in a channel and stratified backward-facing step flow. The investigated OBCs are linear explicit step space extrapolation, Orlanski's monochromatic wave, and pressure extrapolation. Orlanski's and pressure extrapolation open boundary treatment for unsteady and steady flows, respectively, yield little reflection and has proved to be adequate for engineering calculations.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
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